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To provide an up\u2010to\u2010date quantification of the role of aspirin on lung, breast, endometrium, ovary, prostate, bladder, and kidney cancer, we conducted a systematic review and meta\u2010analysis of all observational studies published up to March 2019. We estimated pooled relative risk (RR) of cancer or cancer death for regular aspirin use vs non\u2010use by using random\u2010effects models, and, whenever possible, we investigated dose\u2010 and duration\u2010risk relations. A total of 148 studies were considered. Regular aspirin use was associated to a reduced risk of lung (RR = 0.88, 95% confidence interval [CI] = 0.79\u20100.98), breast (RR = 0.90, 95% CI = 0.85\u20100.95), endometrial (RR = 0.91, 95% CI = 0.84\u20100.98), ovarian (RR = 0.91, 95% CI = 0.85\u20100.97) and prostate (RR = 0.93, 95% CI = 0.89\u20100.96) cancer. However, for most neoplasms, nonsignificant risk reductions were reported in cohort and nested case\u2010control studies and there was between\u2010study heterogeneity. No association was reported for bladder and kidney cancer. No duration\u2010risk relations were observed for most neoplasms, except for an inverse duration\u2010risk relation for prostate cancer. The present meta\u2010analysis confirms the absence of appreciable effect of regular aspirin use on cancers of the bladder and kidney and quantifies small and heterogeneous inverse associations for other cancers considered.<\/jats:p>","DOI":"10.1002\/ijc.33311","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T06:44:26Z","timestamp":1601275466000},"page":"1372-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Aspirin and the risk of nondigestive tract cancers: An updated meta\u2010analysis to 2019"],"prefix":"10.1002","volume":"148","author":[{"given":"Claudia","family":"Santucci","sequence":"first","affiliation":[{"name":"Department of Oncology Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"},{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano  Milan 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