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In this study, we studied survival rates and trends in survival of the largest available cohort of children with cancer (n = 15\u2009779, aged 0\u201018\u2009years) from Egypt between 2007 and 2017, treated at Children's Cancer Hospital Egypt\u2010(CCHE), representing 40% to 50% of all childhood cancers across Egypt. We estimated 5\u2010year overall survival (OS) for 14\u2009808 eligible patients using Kaplan\u2010Meier method, and determined survival trends using Cox regression by single year of diagnosis and by diagnosis periods. We compared age\u2010standardized rates to international benchmarks in England and the United States, identified cancers with inferior survival and provided recommendations for improvement. Five\u2010year OS was 72.1% (95% CI 71.3\u201072.9) for all cancers combined, and survival trends increased significantly by single year of diagnosis (<jats:italic>P<\/jats:italic> &lt;\u2009.001) and by calendar periods from 69.6% to 74.2% (<jats:italic>P<\/jats:italic> &lt;\u2009.0001) between 2007\u20102012 and 2013\u20102017. Survival trends improved significantly for leukemias, lymphomas, CNS tumors, neuroblastoma, hepatoblastoma and Ewing Sarcoma. Survival was significantly lower by 9% and 11.2% (<jats:italic>P<\/jats:italic> &lt;\u2009.001) than England and the United States, respectively. Significantly inferior survival was observed for the majority of cancers. Although survival trends are improving for childhood cancers in Egypt\/CCHE, survival is still inferior in high\u2010income countries. We provide evidence\u2010based recommendations to improve survival in Egypt by reflecting on current obstacles in care, with further implications on practice and policy.<\/jats:p>","DOI":"10.1002\/ijc.33321","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T20:07:29Z","timestamp":1601496449000},"page":"1562-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Temporal trends in childhood cancer survival in Egypt, 2007 to 2017: A large retrospective study of 14\u2009808 children with cancer from the Children's Cancer Hospital Egypt"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8503-9067","authenticated-orcid":false,"given":"Ranin M.","family":"Soliman","sequence":"first","affiliation":[{"name":"Department of Continuing Education University of Oxford  Oxford UK"},{"name":"Health Economics and Value Unit Children's Cancer Hospital 57357 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