{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:13:55Z","timestamp":1791360835436,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2\u2009years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor\u2010specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.<\/jats:p>","DOI":"10.1002\/ijc.33327","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T09:33:51Z","timestamp":1601631231000},"page":"981-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-4293","authenticated-orcid":false,"given":"Thomas","family":"van Doeveren","sequence":"first","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-106X","authenticated-orcid":false,"given":"Jose A.","family":"Nakauma\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"},{"name":"Department of Medical Oncology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"},{"name":"Cancer Computational Biology Center, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-3974","authenticated-orcid":false,"given":"Andrew S.","family":"Mason","sequence":"additional","affiliation":[{"name":"Jack Birch Unit for Molecular Carcinogenesis, Department of Biology The University of York York UK"},{"name":"York Biomedical Research Institute The University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-9102","authenticated-orcid":false,"given":"Geert J. L. H.","family":"van Leenders","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-0812","authenticated-orcid":false,"given":"Tahlita C. M.","family":"Zuiverloon","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-4953","authenticated-orcid":false,"given":"Ellen C.","family":"Zwarthoff","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle C.","family":"Meijssen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique C.","family":"van der Made","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8839-8601","authenticated-orcid":false,"given":"Antoine G.","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Urology, Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"Hendricksen","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute\u2014Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas W. G.","family":"van Rhijn","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute\u2014Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Urology, Caritas St. Josef Medical Center University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-118X","authenticated-orcid":false,"given":"Charlotte S.","family":"Voskuilen","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute\u2014Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7767-7923","authenticated-orcid":false,"given":"Job","family":"van Riet","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"},{"name":"Cancer Computational Biology Center, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-8380","authenticated-orcid":false,"given":"Winand N. M.","family":"Dinjens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2160-5207","authenticated-orcid":false,"given":"Hendrikus J.","family":"Dubbink","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-1477","authenticated-orcid":false,"given":"Harmen J. G.","family":"van de Werken","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"},{"name":"Cancer Computational Biology Center, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-0436","authenticated-orcid":false,"given":"Joost L.","family":"Boormans","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"European Association of Urology Guidelines on upper urinary tract urothelial carcinoma: 2020 update","author":"Roupret M","year":"2020","journal-title":"Eur Urol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203123261108"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2005.01155.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.01.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.11.010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.06.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12650"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2017.11.011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.145"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1814"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1214\/15-AOAS836"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz486"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.052"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.09.046"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2039"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00143","article-title":"Genomic characterization of upper\u2010tract urothelial carcinoma in patients with lynch syndrome","volume":"2","author":"Donahu TF","year":"2018","journal-title":"JCO Precis Oncol"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T10:50:18Z","timestamp":1723719018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2,15]]}},"alternative-id":["10.1002\/ijc.33327"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33327","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,13]]},"assertion":[{"value":"2020-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}