{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:23:16Z","timestamp":1769606596586,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clear cell carcinomas (CCCs) of the gynecologic tract are aggressive tumors with high resistance rate to conventional platinum\u2010based chemotherapies. Currently, the molecular features of these tumors remain largely unknown and there is no targeted therapy available. The aim of our study was to identify anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>) translocations, a potential molecular target for therapy. Ninety\u2010seven patients with gynecologic CCC (62 ovarian, 27 uterine corpus and 8 uterine cervical) were screened for <jats:italic>ALK<\/jats:italic> rearrangement and <jats:italic>ALK<\/jats:italic> copy number gain using an <jats:italic>ALK<\/jats:italic> break\u2010apart fluorescence in situ hybridization probe. The genomic landscape of all cases with <jats:italic>ALK<\/jats:italic> rearrangements and 10 random cases with <jats:italic>ALK<\/jats:italic> copy number gain was queried using a hybrid capture\u2010based DNA next\u2010generation sequencing assay and an Illumina Fusion RNA assay. Findings were then correlated with ALK immunohistochemistry (clone D5F3) expression. <jats:italic>ALK<\/jats:italic> rearrangement was detected in 5% (5\/97) and <jats:italic>ALK<\/jats:italic> copy number gain in 79% (77\/97) of gynecologic CCCs. Next\u2010generation sequencing in <jats:italic>ALK<\/jats:italic>\u2010rearranged CCCs identified a novel <jats:italic>BABAM2<\/jats:italic>\u2010<jats:italic>ALK<\/jats:italic> fusion in one case. <jats:italic>ALK<\/jats:italic> translocation partners were not identified in the remaining cases. Our findings show that <jats:italic>ALK<\/jats:italic> fusion, which is targetable in other cancers, may be a pathogenetic mechanism in a small number of gynecologic CCCs.<\/jats:p>","DOI":"10.1002\/ijc.33330","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T07:55:01Z","timestamp":1602230101000},"page":"459-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of novel <scp><i>ALK<\/i><\/scp> rearrangements in gynecologic clear cell carcinoma"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-5930","authenticated-orcid":false,"given":"Chen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center  New York NY 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