{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:39:13Z","timestamp":1777703953190,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/02688"],"award-info":[{"award-number":["PI12\/02688"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/02276"],"award-info":[{"award-number":["PI17\/02276"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the association between germline genetic variants located within the 3\u2032\u2010untranlsated region (polymorphic 3\u2032UTR, ie, p3UTR) of candidate genes involved in multiple myeloma (MM). We performed a case\u2010control study within the International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting of 3056\u2009MM patients and 1960 controls recruited from eight countries. We selected p3UTR of six genes known to act in different pathways relevant in MM pathogenesis, namely <jats:italic>KRAS<\/jats:italic> (rs12587 and rs7973623), <jats:italic>VEGFA<\/jats:italic> (rs10434), <jats:italic>SPP1<\/jats:italic> (rs1126772), <jats:italic>IRF4<\/jats:italic> (rs12211228) and <jats:italic>IL10<\/jats:italic> (rs3024496). We found that <jats:italic>IL10\u2010<\/jats:italic>rs3024496 was associated with increased risk of developing MM and with a worse overall survival of MM patients. The variant allele was assayed in a vector expressing eGFP chimerized with the <jats:italic>IL10<\/jats:italic> 3\u2032\u2010UTR and it was found functionally active following transfection in human myeloma cells. In this experiment, the A\u2010allele caused a lower expression of the reporter gene and this was also in agreement with the in vivo expression of mRNA measured in whole blood as reported in the GTEx portal. Overall, these data are suggestive of an effect of the <jats:italic>IL10\u2010<\/jats:italic>rs3024496 SNP on the regulation of <jats:italic>IL10<\/jats:italic> mRNA expression and it could have clinical implications for better characterization of MM patients in terms of prognosis.<\/jats:p>","DOI":"10.1002\/ijc.33377","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T17:23:55Z","timestamp":1604597035000},"page":"1887-1894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Common gene variants within 3\u2032\u2010untranslated regions as modulators of multiple myeloma risk and survival"],"prefix":"10.1002","volume":"148","author":[{"given":"Ombretta","family":"Melaiu","sequence":"first","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-5079","authenticated-orcid":false,"given":"Angelica","family":"Macauda","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"},{"name":"Genomic Epidemiology Group German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-2423","authenticated-orcid":false,"given":"Juan","family":"Sainz","sequence":"additional","affiliation":[{"name":"Genomic Oncology Area GENYO. 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