{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:41:20Z","timestamp":1790606480991,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prior studies showed that calcium channel blockers (CCBs) could modify cancer risk, but data on gastric cancer (GC) are limited. We aimed to investigate whether CCBs could modify GC risk in <jats:italic>Helicobacter pylori<\/jats:italic>\u2010eradicated patients. <jats:italic>H pylori<\/jats:italic>\u2010infected patients with hypertension who are aged \u226550 and had received clarithromycin\u2010based triple therapy between 2003 and 2016 were identified from a territory\u2010wide healthcare database. Patients with eradication failure, GC diagnosed within 6 months after HP eradication, and gastric ulcer were excluded. Time\u2010fixed Cox model with one\u2010to\u2010one propensity score matching was used to calculate hazard ratio (HR) of GC with CCBs. Sensitivity analysis using time\u2010dependent multivariable Cox model in which CCB use was treated as time\u2010varying covariate was also performed to address immortal time bias. 17\u2009622 (29.6%) <jats:italic>H pylori<\/jats:italic>\u2010eradicated patients with hypertension were included. During a median follow\u2010up of 8.6\u2009years, 105 (0.6%) developed GC. After PS matching, CCBs were associated with a lower GC risk (HR: 0.56; 95% CI: 0.32\u20100.97). Time\u2010dependent analysis showed consistent result (aHR: 0.50; 95% CI: 0.33\u20100.75). A longer duration of CCB use was associated with even lower GC risk (adjusted HR [aHR]: 0.69; 95% CI: 0.61\u20100.79 for every 1\u2010year increase in use). Long\u2010acting CCBs (aHR: 0.47; 95% CI: 0.29\u20100.76) and dihydropyridines (aHR: 0.49; 95% CI: 0.32\u20100.73) conferred greater benefit than short\u2010acting ones (aHR: 0.60; 95% CI: 0.36\u20101.03) and nondihydropyridines (aHR: 0.76; 95% CI: 0.24\u20102.48). The aHR was 0.57 (95% CI: 0.34\u20100.97) for noncardia and 0.59 (95% CI: 0.27\u20101.31) for cardia cancer. Use of CCBs was associated with lower risk of GC development in <jats:italic>H pylori<\/jats:italic>\u2010eradicated patients, in a duration\u2010 and dose\u2010response manner.<\/jats:p>","DOI":"10.1002\/ijc.33379","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T17:30:11Z","timestamp":1604597411000},"page":"2148-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Calcium channel blockers are associated with lower gastric cancer risk: A territory\u2010wide study with propensity score analysis"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-5210","authenticated-orcid":false,"given":"Bofei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Hong Kong, Queen Mary Hospital  Pokfulam Road Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Shing","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Road Hong Kong"},{"name":"Department of Medicine The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian Yu\u2010Hong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong, Queen Mary Hospital  Pokfulam Road Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-1059","authenticated-orcid":false,"given":"Wai Keung","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Road Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Surgery 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