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However, few studies have investigated the correlation between these immunological events and clinical consequences in cervical cancer. We measured the levels of numerous inflammatory mediators and frequencies of regulatory T cells (Tregs), myeloid\u2010derived suppressor cells (MDSCs) and mucosal\u2010associated invariant T (MAIT) cells in peripheral blood (PB) of cervical cancer patients. Cervical cancer patients showed elevated production of interleukin (IL)\u201018 and plasma C\u2010C chemokine ligand (CCL) 3\/5. Meanwhile, an accumulation of C\u2010C chemokine receptor 5 (CCR5) monocytic (Mo)\u2010MDSCs and Tregs was observed. The cervical cancer group displayed increased frequencies of CD8<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>and highly activated CD38<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup>MAIT cells, and reduction of double\u2010negative (DN) and PD1(CD279<jats:sup>+<\/jats:sup>) DN MAIT cells. Importantly, it was demonstrated that MAIT cells were positively related to Mo\u2010MDSCs. Furthermore, an elevated concentration of PD1(CD279<jats:sup>+<\/jats:sup>) DN MAIT cells was significantly related to increased progression\u2010free survival of patients with cervical cancer. In conclusion, our study suggests that the combined action of Mo\u2010MDSCs and MAIT cells might be associated with the progression of cervical cancer, and the frequency of DN MAIT cells in the peripheral blood mononuclear cells was associated with the survival benefit of patients.<\/jats:p>","DOI":"10.1002\/ijc.33411","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T17:09:14Z","timestamp":1606496954000},"page":"1499-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The combined action of monocytic myeloid\u2010derived suppressor cells and mucosal\u2010associated invariant T cells promotes the progression of cervical cancer"],"prefix":"10.1002","volume":"148","author":[{"given":"Zhimin","family":"Lu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University 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