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Metabolic changes are a critical factor in CAC; however, the mechanisms through which tumors inhibit adipogenesis and promote lipolysis are poorly understood. To clarify these mechanisms, we investigated adipogenesis\u2010limiting factors released by tumors in a cell culture system. We identified proliferin\u20101 (PLF\u20101), a member of the growth hormone\/prolactin gene family, as a key factor secreted from certain tumors that inhibited preadipocyte maturation and promoted the lipolysis of mature adipocytes. Importantly, mice transplanted with PLF\u20101\u2010depleted tumor cells were protected from fat loss due to CAC. These data show that tumor\u2010secreted PLF\u20101 plays an essential role in impaired adipogenesis and accelerated lipolysis and is a potential therapeutic target against CAC.<\/jats:p>","DOI":"10.1002\/ijc.33418","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T10:26:44Z","timestamp":1606732004000},"page":"1982-1992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tumor\u2010secreted proliferin\u20101 regulates adipogenesis and lipolysis in cachexia"],"prefix":"10.1002","volume":"148","author":[{"given":"Tuan Duc","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Immunology Kanazawa University Graduate School of Medical Sciences  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Miyatake","sequence":"additional","affiliation":[{"name":"Department of Immunology Kanazawa University Graduate School 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