{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:05:49Z","timestamp":1789707949241,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"The National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA006973"],"award-info":[{"award-number":["P30CA006973"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201016\u20101\u20100764"],"award-info":[{"award-number":["W81XWH\u201016\u20101\u20100764"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201016\u20101\u20100765"],"award-info":[{"award-number":["W81XWH\u201016\u20101\u20100765"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201016\u20101\u20100766"],"award-info":[{"award-number":["W81XWH\u201016\u20101\u20100766"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cystic fibrosis (CF) carriers carrying one defective copy of a <jats:italic>CFTR<\/jats:italic> germline mutation are common in the general population. A recent study reported associations of CF carriers with risk for cancers of digestive organs and pancreatic cancer. In the current study, we assessed associations of <jats:italic>CFTR<\/jats:italic> F508del carriers with the risk for 54 types of cancers in the UK Biobank, a large population\u2010based study. In Caucasians, compared to the carrier rate of 3.15% (12\u2009357\/392274) in noncancer subjects, the rate was significantly higher in cancer patients overall (2621\/79619 = 3.29%), especially in patients with colorectal cancer (247\/6667 = 3.70%), cancers of gallbladder and biliary tract (21\/351 = 5.98%), thyroid cancer (30\/665 = 4.51%) and unspecified non\u2010Hodgkin's lymphoma (74\/1805 = 4.10%), all <jats:italic>P<\/jats:italic> \u2264\u2009.05. In contrast, the carrier rate in patients with cancers of lung and bronchus was significantly lower (89\/3463 = 2.57%), <jats:italic>P<\/jats:italic> =\u2009.05. The association of <jats:italic>CFTR<\/jats:italic> F508del carriers with these types of cancer remained significant after adjusting for respective cancer\u2010specific risk factors. For pancreatic cancer, although a higher carrier rate (38\/1004 = 3.78%) was found in patients with this cancer, the difference was not statistically significant (<jats:italic>P\u2009=<\/jats:italic> .26). This null association was unlikely due to lack of statistical power; the large sample size of our study had &gt;80% power, at a significance level of .05, to detect an association of &gt;1.5\u2010fold increased risk. In conclusion, the identified associations of <jats:italic>CFTR<\/jats:italic> F508del carriers with multiple types of cancer may have potential biological and clinical implications if confirmed in independent study populations.<\/jats:p>","DOI":"10.1002\/ijc.33431","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T01:09:41Z","timestamp":1607648981000},"page":"1658-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cystic fibrosis F508del carriers and cancer risk: Results from the <scp>UK<\/scp> Biobank"],"prefix":"10.1002","volume":"148","author":[{"given":"Zhuqing","family":"Shi","sequence":"first","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-5108","authenticated-orcid":false,"given":"Rong","family":"Na","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Kyle","family":"Resurreccion","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lilly","family":"Zheng","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hulick","sequence":"additional","affiliation":[{"name":"Department of Medicine NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Helfand","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"},{"name":"Department of Surgery NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Talamonti","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"},{"name":"Department of Surgery NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-8752","authenticated-orcid":false,"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Program for Personalized Cancer Care NorthShore University HealthSystem  Evanston Illinois USA"},{"name":"Department of Surgery NorthShore University HealthSystem  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465810386051"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00576-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs481"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2393-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914912117"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.03.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0201-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074534"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.218"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.01.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7524148"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-5-21"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/ijc.33431","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:10:54Z","timestamp":1693617054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/ijc.33431"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33431","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,18]]},"assertion":[{"value":"2020-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}