{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:09:44Z","timestamp":1790111384094,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast density is strongly associated with breast cancer risk; however, studies on the association between density changes and breast cancer risk have controversial results. The aim of our study was to determine the association between breast density changes and breast cancer risk in East\u2010Asian women. We included 3\u2009301\u2009279 women aged \u226540\u2009years screened for breast cancer twice during 2009 to 2010 and 2011 to 2012. Data were obtained from the National Health Insurance Service (NHIS) database. Breast density was evaluated using the Breast Imaging\u2010Reporting and Data System (BI\u2010RADS). Relative risk (RR) and 5\u2010year risk of developing breast cancer according to density category changes were calculated. Overall, 23.0% of the women had a higher breast density and 22.2% of the women had a lower breast density in second screening compared to the first. An increase in the BI\u2010RADS density category between two subsequent mammographic screenings was associated with an increase in breast cancer risk and vice versa in terms of RR. The 5\u2010year breast cancer risk was affected by the initial BI\u2010RADS density category, changes in density category and patients' characteristics such as age, menopausal status and family history of breast cancer. In patients with breast cancer family history, the 5\u2010year breast cancer risk was prominent, at a maximum of 2.39% (95% CI = 1.23\u20103.55) in women with breast density category of 2 to 4. Changes in the BI\u2010RADS density category were associated with breast cancer risk. Longitudinal measures of BI\u2010RADS density may be helpful in identifying high\u2010risk women, especially those with a breast cancer family history.<\/jats:p>","DOI":"10.1002\/ijc.33455","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T15:29:04Z","timestamp":1608823744000},"page":"2674-2684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association between changes in mammographic density category and the risk of breast cancer: A nationwide cohort study in <scp>East\u2010Asian<\/scp> women"],"prefix":"10.1002","volume":"148","author":[{"given":"Soyeoun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Health Sciences Hanyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-3184","authenticated-orcid":false,"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66546-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.03.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S144918"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.16.054"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002335"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-4054-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.5.959"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.3.457"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3348\/jkrs.2000.42.6.1009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih\/e2014020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0798"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.138"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2942"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws446"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk066"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0035"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz149"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-1047"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199912000-00006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28825"},{"key":"e_1_2_10_24_1","first-page":"1","volume-title":"Medical Statistics at a Glance","author":"Petrie A","year":"2013"},{"key":"e_1_2_10_25_1","volume-title":"Cancer Mortality and Morbidity Patterns in the US Population: An Interdisciplinary Approach","author":"Manton KG","year":"2008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9345-9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs327"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29275"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0551-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.07.003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.5.358"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01147.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-018-0932-z"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2102"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1256-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-011-0777-3"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-485"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2018.04.002"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2014.15.5.578"},{"key":"e_1_2_10_40_1","first-page":"15","article-title":"Interpretive volume and inter\u2010radiologist agreement on assessing breast density","volume":"15","author":"Jo H\u2010M","year":"2018","journal-title":"J Korean Soc Breast Screening"},{"key":"e_1_2_10_41_1","volume-title":"Epidemiology: Beyond the Basics","author":"Szklo M","year":"2014"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-014-0027-z"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12178"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2017.01.001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058460120937381"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.16.16561"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.01.001"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151261"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152062"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214661"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.186"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:26:05Z","timestamp":1693221965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ijc.33455"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33455","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"2020-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}