{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:53:19Z","timestamp":1785196399305,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In order to characterize the somatic mutational landscape and to investigate the prognosis predicting factors of ovary\u2010originating PMP, we examined 830 cases of PMP and identified 16 patients with PMP that originated from the ovary. Whole\u2010exome sequencing (WES) was performed on 12 cases using formalin\u2010fixed, paraffin\u2010embedded (FFPE) tissue samples. We found that 25% (3\/12) of the patients carried mutations in cancer driver genes, including TP53, ATM and SETD2, and 16.7% (2\/12) of the patients carried mutations in cancer driver genes, including ATRX, EP300, FGFR2, KRAS, NOCR1 and RB1. The MUC16 (58.33%), BSN (41.67%), PCNT (41.67%), PPP2R5A (41.67%), PRSS36 (41.67%), PTPRK (41.67%) and SBF1 (41.67%) genes presented the highest mutational frequencies. The PI3K\u2010Akt signaling pathway, human papillomavirus infection pathway, cell skeleton, cell adhesion, and extracellular matrix and membrane proteins were the major pathways or functions that were affected. Patients were followed up to 174\u2009months (median: 48.26\u2009months). The 5\u2010year OS rate for all patients was 71.2% and the median OS was not reached. PTPRK mutations, presurgical CA199 level, completeness of cytoreduction (CCR) and peritoneal cancer index (PCI) were identified as potential predictive factors for patient survival. In conclusion, the mutational landscape for ovary\u2010originating PMP was revealed and exhibited unique features distinct from appendix\u2010originating PMP. PTPRK, CA199, CCR and PCI may predict patient survival.<\/jats:p>","DOI":"10.1002\/ijc.33460","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T04:21:20Z","timestamp":1609993280000},"page":"2036-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary"],"prefix":"10.1002","volume":"148","author":[{"given":"Bing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Yao","sequence":"additional","affiliation":[{"name":"HaploX Biotechnology, Co., Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Myxoma Aerospace 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