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Although many studies have considered the association between genital powder use and ovarian cancer risk, the relationship between genital powder use and uterine cancer is less well\u2010studied. We pooled data from four large, prospective cohorts (the Nurses' Health Study, the Nurses' Health Study II, the Sister Study and the Women's Health Initiative \u2010 Observational Study). We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for prespecified confounders. In total, 209\u2009185 women were included, with 37% reporting ever genital powder use. Over a mean 14.5\u2009years of follow\u2010up, 3272 invasive uterine cancers were diagnosed. There was no overall association between ever genital powder use and uterine cancer (HR = 1.01, 95% CI: 0.94\u20101.09), with little difference observed for frequent (\u22651 times\/week) vs never use (HR = 1.05, 95% CI: 0.95\u20101.16; <jats:italic>P<\/jats:italic>\u2010for\u2010trend = .46). Long\u2010term use (&gt;20\u2009years; HR = 1.12, 95% CI: 0.96\u20101.31; <jats:italic>P<\/jats:italic>\u2010for\u2010trend = 0.14) was associated with a small, but not statistically significant, increase in risk, compared to never use. There were not clear differences by uterine cancer histologic subtypes or across strata of relevant covariates, including race\/ethnicity, follow\u2010up time, menopausal status and body mass index. The results of this large, pooled analysis do not support a relationship between the use of genital powder and uterine cancer, although the positive associations observed for long\u2010term use may merit further consideration.<\/jats:p>","DOI":"10.1002\/ijc.33470","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T08:42:24Z","timestamp":1610700144000},"page":"2692-2701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genital powder use and risk of uterine cancer: A pooled analysis of prospective studies"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-1349","authenticated-orcid":false,"given":"Katie M.","family":"O'Brien","sequence":"first","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-7046","authenticated-orcid":false,"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, University of Washington  Seattle Washington USA"},{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1539-6090","authenticated-orcid":false,"given":"Britton","family":"Trabert","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice R.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Biostatistics and Computational Biology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee T.","family":"Fortner","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee A.","family":"D'Aloisio","sequence":"additional","affiliation":[{"name":"Social and Scientific Systems, Inc.  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Kaunitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Florida College of Medicine\u2010 Jacksonville  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-0836","authenticated-orcid":false,"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","first-page":"753","article-title":"Characteristics of women who use perineal powders","volume":"92","author":"Rosenblatt KA","year":"1998","journal-title":"Obs Gynecol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1971.tb00267.x"},{"key":"e_1_2_11_4_1","unstructured":"World Health Organization International Agency for Research on Cancer.IARC monographs on the evaluation of carcinogenic risks to humans: carbon black titanium dioxide and talc. 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