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We examined whether the incidence and risk factors for CBC differed by race\/ethnicity in the United States. Women with a first invasive Stage I\u2010IIB breast cancer diagnosis at ages 20\u201074\u2009years between 2000 and 2015 in the Surveillance, Epidemiology, and End Results Program (SEER) 18 registries were followed through 2016 for a diagnosis of invasive CBC \u22651 year after the first breast cancer diagnosis. We used cause\u2010specific Cox proportional hazards models to test the association between race\/ethnicity and CBC, adjusting for age, hormone receptor status, radiation therapy, chemotherapy and stage at first diagnosis, and evaluated the impact of contralateral prophylactic mastectomy, socioeconomic status, and insurance status on the association. After a median follow\u2010up of 5.9\u2009years, 9247 women (2.0%) were diagnosed with CBC. Relative to non\u2010Hispanic (NH) White women, CBC risk was increased in NH Black women (hazard ratio = 1.44, 95% CI 1.35\u20101.54) and Hispanic women (1.11, 95% CI 1.02\u20101.20), with the largest differences among women diagnosed at younger ages. Adjustment for contralateral prophylactic mastectomy, socioeconomic status and health insurance did not explain the associations. Therefore, non\u2010Hispanic Black and Hispanic women have an increased risk of CBC that is not explained by clinical or socioeconomic factors collected in SEER. Large studies of diverse breast cancer survivors with detailed data on treatment delivery and adherence are needed to inform interventions to reduce this disparity.<\/jats:p>","DOI":"10.1002\/ijc.33501","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T10:00:54Z","timestamp":1612605654000},"page":"2748-2758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Race, ethnicity and risk of second primary contralateral breast cancer in the United States"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2024-0015","authenticated-orcid":false,"given":"Gordon P.","family":"Watt","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-8003","authenticated-orcid":false,"given":"Esther M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa V.","family":"Bandera","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology and Health Outcomes Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Malone","sequence":"additional","affiliation":[{"name":"Epidemiology Program, Division of Public Health Sciences Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-7635","authenticated-orcid":false,"given":"Julia A.","family":"Knight","sequence":"additional","affiliation":[{"name":"Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Troester","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonine L.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21583"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.2495"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116565"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0874-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.08.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3439-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1560-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1657-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7060133"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.07.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18865\/ed.28.4.565"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp181"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3151-z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176417"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001698"},{"key":"e_1_2_10_18_1","unstructured":"National Cancer Institute D Surveillance Research Program. 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