{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:51:07Z","timestamp":1788807067430,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF\u201016\u2010140"],"award-info":[{"award-number":["BCRF\u201016\u2010140"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF\u201019\u2010034"],"award-info":[{"award-number":["BCRF\u201019\u2010034"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Emerging evidence suggests that normal weight postmenopausal women with a relative excess of body fat are at increased breast cancer risk. However, little is known about the associations between obesity\u2010related blood markers and risk of breast cancer among these individuals. In this prospective study comprising 58\u2009629 normal weight postmenopausal women (body mass index between 18.5\u2009kg\/m<jats:sup>2<\/jats:sup> and 24.9\u2009kg\/m<jats:sup>2<\/jats:sup>) who were enrolled in the UK Biobank cohort between 2006 and 2010, we examined the associations of glycated hemoglobin, triglycerides, high\u2010density lipoprotein cholesterol, C\u2010reactive protein (CRP), testosterone and sex hormone\u2010binding globulin (SHBG) with risk of breast cancer. A total of 1268 postmenopausal breast cancer cases were ascertained during a median follow\u2010up period of 7\u2009years. Women with CRP, total testosterone and free testosterone (FT) levels in the highest quintile had increased risk of breast cancer compared to those in the lowest quintile (HR<jats:sub>Q5 vs Q1<\/jats:sub>: 1.35, 95% confidence interval [CI]: 1.12\u20101.63, HR <jats:sub>Q5 vs Q1<\/jats:sub>: 1.47, 95% CI: 1.20\u20101.80 and HR <jats:sub>Q5 vs Q1<\/jats:sub>: 1.53, 95% CI: 1.23\u20101.90, respectively), whereas those with SHBG in the highest quintile had reduced risk (HR <jats:sub>Q5 vs Q1<\/jats:sub>: 0.70, 95% CI: 0.56\u20100.88). These associations were attenuated but persisted after additional adjustment for BMI, fat mass index (whole body fat mass [kg]\/height [m<jats:sup>2<\/jats:sup>]) or waist circumference and after mutual adjustment for testosterone, CRP and\/or SHBG. Our study suggests that the risk of postmenopausal breast cancer among normal weight women is increased in association with relatively high levels of CRP and testosterone and with relatively low levels of SHBG.<\/jats:p>","DOI":"10.1002\/ijc.33508","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T20:00:26Z","timestamp":1612987226000},"page":"42-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The association of prediagnostic circulating levels of cardiometabolic markers, testosterone and sex hormone\u2010binding globulin with risk of breast cancer among normal weight postmenopausal women in the <scp>UK<\/scp> Biobank"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-2945","authenticated-orcid":false,"given":"Rhonda S.","family":"Arthur","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Dannenberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York 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