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Reports have implicated miRNAs in the diagnosis, treatment and prognosis of hematological malignancies. In our study, we evaluated the expression profiles of miR\u201017\u20103p in plasma and bone marrow mononuclear cells of monoclonal gammopathy of undetermined significance (MGUS) and MM patients and healthy subjects. The results showed that the plasma and mononuclear cell expression levels of miR\u201017\u20103p in MM patients were higher than those in MGUS patients and normal controls. In addition, the expression of miR\u201017\u20103p was positively correlated with diagnostic indexes, such as marrow plasma cell abundance and serum M protein level, and positively correlated with the International Staging System stage of the disease. Receiver operating characteristic curve analysis suggested that miR\u201017\u20103p might be a diagnostic index of MM. Moreover, miR\u201017\u20103p regulated cell proliferation, apoptosis and the cell cycle through P21 in MM cell lines and promoted MM tumor growth in vivo. Furthermore, we predicted and verified LMLN as a functional downstream target gene of miR\u201017\u20103p. Negatively regulated by miR\u201017\u20103p, LMLN inhibits MM cell growth, exerting a tumor suppressive function through P21. Taken together, our data identify miR\u201017\u20103p as a promising diagnostic biomarker for MM in the clinic and unveil a new miR\u201017\u20103p\u2010LMLN\u2010P21 axis in MM progression.<\/jats:p>","DOI":"10.1002\/ijc.33528","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T04:35:25Z","timestamp":1613882125000},"page":"3071-3085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<scp>miR<\/scp>\u201017\u20103p promotes the proliferation of multiple myeloma cells by downregulating <scp>P21<\/scp> expression through <scp>LMLN<\/scp> inhibition"],"prefix":"10.1002","volume":"148","author":[{"given":"Pu","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Henan Hematology Institute  Zhengzhou Henan 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