{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:10:23Z","timestamp":1790111423887,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201010\u20101\u201002802"],"award-info":[{"award-number":["W81XWH\u201010\u20101\u201002802"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Results of studies assessing intrauterine device (IUD) use and ovarian cancer risk are inconsistent. We examined the association between IUD use, including duration, type and timing of use, and ovarian cancer risk using three population\u2010based studies. Data from the New England Case\u2010Control Study (NEC) and two prospective cohort studies, the Nurses' Health Studies (NHS\/NHSII), were included in the analysis. Information on IUD use was collected by in\u2010person interview in NEC and by biennial questionnaire in NHS\/NHSII. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) in NEC and Cox regression to calculate hazard ratios (HR) and 95% CI in NHS\/NHSII. We used meta\u2010analysis to combine the NEC and the pooled NHS\/NHSII results. Overall, IUD use was not associated with epithelial ovarian cancer risk (OR = 0.96, 95% CI: 0.81\u20101.14 in NEC; HR = 0.89, 95% CI: 0.69\u20101.15 in NHS\/NHSII; combined RR = 0.94, 95% CI: 0.81\u20101.08). Among IUD users, older age at first use was associated with increased ovarian cancer risk (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend = .03). We did not observe significant associations by IUD type or duration of use. In conclusion, IUD use was not associated with ovarian cancer risk in our study.\n                  <\/jats:p>","DOI":"10.1002\/ijc.33531","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T08:02:58Z","timestamp":1614326578000},"page":"75-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intrauterine device use and risk of ovarian cancer: Results from the\n                    <scp>New England Case\u2010Control<\/scp>\n                    study and\n                    <scp>Nurses' Health Studies<\/scp>"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-9615","authenticated-orcid":false,"given":"Jiaxi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-2181","authenticated-orcid":false,"given":"Naoko","family":"Sasamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Babic","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison F.","family":"Vitonis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Titus","sequence":"additional","affiliation":[{"name":"Public Health, Muskie School of Public Service University of Southern Maine  Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-7046","authenticated-orcid":false,"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Cancer Epidemiology Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2017.10.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000179274.24200.9d"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2016.09.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60167-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200003000-00004"},{"key":"e_1_2_10_7_1","unstructured":"American College of Obstetricians and GynecologistsIncreasing access to contraceptive implants and intrauterine devices to reduce unintended pregnancy. 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