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Evidence is more limited from China, where cancer rates, drinking patterns and alcohol tolerability differ importantly from Western populations. The prospective China Kadoorie Biobank recruited &gt;512\u2009000 adults aged 30 to 79\u2009years from 10 diverse areas during 2004 to 2008, recording alcohol consumption patterns by a standardised questionnaire. Self\u2010reported alcohol consumption was estimated as grams of pure alcohol per week based on beverage type, amount consumed per occasion and drinking frequency. After 10\u2009years of follow\u2010up, 26\u2009961 individuals developed cancer. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) relating alcohol consumption to incidence of site\u2010specific cancers. Overall, 33% (n = 69\u2009734) of men drank alcohol regularly (ie, \u2265weekly) at baseline. Among male current regular drinkers, alcohol intake showed positive dose\u2010response associations with risks of cancers in the oesophagus (655 events; HR = 1.98 [95%CI 1.79\u20102.18], per 280\u2009g\/wk), mouth and throat (236; 1.74 [1.48\u20102.05]), liver (573; 1.52 [1.31\u20101.76]), colon\u2010rectum (575; 1.19 [1.00\u20101.43]), gallbladder (107; 1.60 [1.16\u20102.22]) and lung (1017; 1.25 [1.10\u20101.42]), similarly among never\u2010 and ever\u2010regular smokers. After adjustment for total alcohol intake, there were greater risks of oesophageal cancer in daily drinkers than nondaily drinkers and of liver cancer when drinking without meals. The risks of oesophageal cancer and lung cancer were greater in men reporting flushing after drinking than not. In this male population, alcohol drinking accounted for 7% of cancer cases. Among women, only 2% drank regularly, with no clear associations between alcohol consumption and cancer risk. Among Chinese men, alcohol drinking is associated with increased risks of cancer at multiple sites, with certain drinking patterns (eg, daily, drinking without meals) and low alcohol tolerance further exacerbating the risks.<\/jats:p>","DOI":"10.1002\/ijc.33538","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T13:18:43Z","timestamp":1614345523000},"page":"522-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Alcohol drinking and risks of total and site\u2010specific cancers in China: A 10\u2010year prospective study of 0.5 million adults"],"prefix":"10.1002","volume":"149","author":[{"given":"Pek Kei","family":"Im","sequence":"first","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona 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