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Adrenal metastases treated with SBRT (\u226412 fractions, biologically effective dose [BED10]\u2009\u2265\u200950\u2009Gy), 3DCRT\/IMRT (&gt;12 fractions, BED10\u2009\u2265\u200950\u2009Gy) or Pall\u2010RT (BED10\u2009&lt;\u200950\u2009Gy) were eligible for this analysis. In addition to unadjusted FFLP (Kaplan\u2010Meier\/log\u2010rank), we calculated the competing\u2010risk\u2010adjusted local recurrence rate (CRA\u2010LRR). Three hundred twenty\u2010six patients with 366 metastases were included by 21 centers (median follow\u2010up: 11.7\u00a0months). Treatment was SBRT, 3DCRT\/IMRT and Pall\u2010RT in 260, 27 and 79 cases, respectively. Most frequent primary tumors were non\u2010small\u2010cell lung cancer (NSCLC; 52.5%), SCLC (16.3%) and melanoma (6.7%). Unadjusted FFLP was higher after SBRT vs Pall\u2010RT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026) while numerical differences in CRA\u2010LRR between groups did not reach statistical significance (1\u2010year CRA\u2010LRR: 13.8%, 17.4% and 27.7%). OS was longer after SBRT vs other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and increased in patients with locally controlled metastases in a landmark analysis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Toxicity was mostly mild; notably, four cases of adrenal insufficiency occurred, two of which were likely caused by immunotherapy or tumor progression. Radiotherapy for adrenal metastases was associated with a mild toxicity profile in all groups and a favorable 1\u2010year CRA\u2010LRR after SBRT or 3DCRT\/IMRT. One\u2010year FFLP was associated with longer OS. Dose\u2010response analyses for the dataset are underway.<\/jats:p>","DOI":"10.1002\/ijc.33546","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:22:38Z","timestamp":1615206158000},"page":"358-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Stereotactic or conformal radiotherapy for adrenal metastases: Patient characteristics and outcomes in a multicenter analysis"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-3332","authenticated-orcid":false,"given":"Daniel","family":"Buergy","sequence":"first","affiliation":[{"name":"Universit\u00e4tsmedizin Mannheim, Medizinische Fakult\u00e4t Mannheim, Universit\u00e4t Heidelberg, Klinik f\u00fcr Strahlentherapie und Radioonkologie  Mannheim 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