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Several studies indicate a critical role of AP\u20102\u03b2 in the development of tissues and organs of ectodermal, neuroectodermal and also mesodermal origin. Germline mutation of <jats:italic>TFAP2B<\/jats:italic> is known to cause the Char syndrome, an autosomal dominant disorder characterized by facial dysmorphism, patent ductus arteriosus and anatomical abnormalities of the fifth digit. Furthermore, single\u2010nucleotide polymorphisms in <jats:italic>TFAP2B<\/jats:italic> were linked to obesity and specific personality traits. In neoplasias, AP\u20102\u03b2 was first described in alveolar rhabdomyosarcoma. Immunohistochemical staining of AP\u20102\u03b2 is a recommended ancillary test for the histopathological diagnosis of this uncommon childhood malignancy. In neuroblastoma, AP\u20102\u03b2 supports noradrenergic differentiation. Recently, the function of AP\u20102\u03b2 in breast cancer (BC) has gained interest. AP\u20102\u03b2 is associated with the lobular BC subtype. Moreover, AP\u20102\u03b2 controls BC cell proliferation and has a prognostic impact in patients with BC. This review provides a comprehensive overview of the current knowledge about AP\u20102\u03b2 and its function in organ development, differentiation and tumorigenesis.<\/jats:p>","DOI":"10.1002\/ijc.33558","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T10:08:46Z","timestamp":1615802926000},"page":"1221-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Transcription factor <scp>AP<\/scp>\u20102beta in development, differentiation and tumorigenesis"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-6209","authenticated-orcid":false,"given":"Mieke","family":"Raap","sequence":"first","affiliation":[{"name":"Institute of Pathology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gierendt","sequence":"additional","affiliation":[{"name":"Institute of Pathology 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