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However, the association between irAEs and antitumor efficacy in HCC patients remains unknown. All patients with HCC treated with anti\u2010PD\u20101 antibodies from July 2018 to November 2019 were analyzed and divided into different groups according to their irAEs' status. In total, 101 HCC patients, including 21 (20.8%) patients who presented with irAEs (irAEs<jats:sup>+<\/jats:sup>), were enrolled. Among the adverse events, rash (n\u00a0=\u00a09, 8.9%) was the most frequent irAE, followed by mucositis (n\u00a0=\u00a03, 3.0%) and thyroiditis (n\u00a0=\u00a03, 3.0%). Patients in the irAEs<jats:sup>+<\/jats:sup> group showed a higher tumor response rate than those in the irAEs<jats:sup>\u2212<\/jats:sup> group (overall response rate: 28.6% vs 6.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011; disease control rate: 85.7% vs 60.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.028). The median progression\u2010free survival (PFS) times were 14.8\u00a0months in the irAEs<jats:sup>+<\/jats:sup> group and 4.1\u00a0months in the irAEs<jats:sup>\u2212<\/jats:sup> group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Further analysis based on the presence or absence of rash showed that the PFS of the patients in the irAEs<jats:sup>+<\/jats:sup>\/rash<jats:sup>+<\/jats:sup> group was better than that of those in the irAEs<jats:sup>+<\/jats:sup>\/rash<jats:sup>\u2212<\/jats:sup> or irAEs<jats:sup>\u2212<\/jats:sup> group (all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Multivariate analysis showed that irAEs were an independent prognostic factor for PFS (hazard ratio [HR]: 0.22, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). Thus, the occurrence of irAEs, especially rash, was associated with markedly improved PFS. Awareness of irAEs may help classify the subtype of HCC patients with an unprecedented survival benefit from anti\u2010PD\u20101 antibodies.<\/jats:p>","DOI":"10.1002\/ijc.33609","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T06:57:48Z","timestamp":1619161068000},"page":"959-966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Immune\u2010related adverse events predict responses to <scp>PD<\/scp>\u20101 blockade immunotherapy in hepatocellular carcinoma"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-6093","authenticated-orcid":false,"given":"Lianghe","family":"Lu","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Hepatobiliary Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Xing","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pancreatobiliary Surgery Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Hepatobiliary Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Ling","sequence":"additional","affiliation":[{"name":"Collaborative 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Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xie","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Pathology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-3463","authenticated-orcid":false,"given":"Rongping","family":"Guo","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, State 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