{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:26:49Z","timestamp":1781299609981,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020T130132"],"award-info":[{"award-number":["2020T130132"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017340","name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","doi-asserted-by":"publisher","award":["2019B030301004"],"award-info":[{"award-number":["2019B030301004"]}],"id":[{"id":"10.13039\/100017340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502046"],"award-info":[{"award-number":["81502046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The etiology of hepatoblastoma is largely unknown due to the rarity of this disease. Nucleotide excision repair (NER), a versatile system in repairing DNA damage, is highly implicated in carcinogenesis. However, it remains unclear whether single nucleotide polymorphisms (SNPs) of genes in the NER pathway are related to hepatoblastoma risk. A total of 313 Chinese children diagnosed with hepatoblastoma and 1446 controls were recruited from seven hospitals across China. TaqMan assay was adopted to genotype 19 SNPs in NER pathway genes including <jats:italic>ERCC1<\/jats:italic>, <jats:italic>XPA<\/jats:italic>, <jats:italic>XPC<\/jats:italic>, <jats:italic>XPD<\/jats:italic>, <jats:italic>XPF<\/jats:italic> and <jats:italic>XPG<\/jats:italic>. Of them, only two SNPs in <jats:italic>XPC<\/jats:italic> gene predisposed to hepatoblastoma risk. The <jats:italic>XPC<\/jats:italic> rs2607775 polymorphism significantly contributed to hepatoblastoma risk (dominant model: adjusted OR\u00a0=\u00a01.44, 95% CI\u00a0=\u00a01.01\u20102.05, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.046). However, <jats:italic>XPC<\/jats:italic> rs1870134 conferred a significantly decreased risk of hepatoblastoma in recessive model (adjusted OR\u00a0=\u00a00.50, 95% CI\u00a0=\u00a00.26\u20100.98, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.042). Stratified analysis revealed that rs2607775 CG\/GG genotype, rs1870134 CC genotype and four to five risk genotypes were associated with the risk of hepatoblastoma under certain subgroups. The significant relationships were confirmed by haplotype analyses and false\u2010positive report probability analyses. In addition, expression quantitative trait locus analysis suggested that rs2607775 G increased expression of <jats:italic>XPC<\/jats:italic> mRNA. Collectively, our discover a promising candidate <jats:italic>XPC<\/jats:italic> gene as a biomarker for the risk of hepatoblastoma.<\/jats:p>","DOI":"10.1002\/ijc.33722","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T04:21:12Z","timestamp":1625199672000},"page":"1649-1658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic variations in nucleotide excision repair pathway genes and hepatoblastoma susceptibility"],"prefix":"10.1002","volume":"149","author":[{"given":"Zhenjian","family":"Zhuo","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Central Laboratories Guangdong Second Provincial General Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Children Hospital and Women Health Center of Shanxi  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children's Major Disease Research Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children's Hospital  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":false,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2016.12.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890901)64:5<1082::aid-cncr2820640520>3.0.co;2-g"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526619875228"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-019-0411-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.12676"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14134"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30598-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/children6010001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24215"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.09.020"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.03.044"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601651"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.13.4.297"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11191"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207499"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00506"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-019-0135-z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.33063"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S241100"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3182"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.46120"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2020.06.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1553"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056154"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.06.004"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.08.002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32371"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0361-5"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12836"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20098"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14827"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-016-3989-8"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.023"},{"issue":"9","key":"e_1_2_11_38_1","first-page":"648","article-title":"Pediatric lung lesions: a clinicopathological study of 215 cases","volume":"44","author":"Niu H","year":"2015","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"3","key":"e_1_2_11_39_1","first-page":"849","article-title":"Genetic variations in base excision repair pathway genes and risk of hepatoblastoma: a seven\u2010center case\u2010control study","volume":"11","author":"Zhuo Z","year":"2021","journal-title":"Am J Cancer Res"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh075"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.01.003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.03.003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12088"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26220"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28693"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.05.011"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7952"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9870"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.13.3554"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf469"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1568-7864(02)00222-7"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i3.307"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S113055"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33722","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:54:12Z","timestamp":1692237252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,10]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/ijc.33722"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33722","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,10]]},"assertion":[{"value":"2021-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}