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The combination of Olaparib and radiotherapy for TNBC is currently evaluated in the Phase I RADIOPARP trial. RADIOPARP is a monocentric prospective open\u2010label Phase I dose\u2010escalation trial evaluating the combination of breast radiotherapy and Olaparib in TNBC patients with inflammatory, locoregionally advanced or metastatic disease, or with residual disease after neoadjuvant chemotherapy. Olaparib was orally given at increasing dose levels (50, 100, 150 or 200\u2009mg twice a day [BID]); radiotherapy consisted of 50\u2009Gy to the breast or chest wall with or without lymph node irradiation. Twenty\u2010four TNBC patients were enrolled between September 2017 and November 2019. Olaparib was escalated to 200\u2009mg BID without dose\u2010limiting toxicities. At 1\u2010year follow\u2010up, no treatment\u2010related grade\u2009\u22653 toxicity was observed. One patient (4.2%) had persistent grade 2 adverse events (breast pain, fibrosis and deformity). There was no cardiac, pulmonary or digestive toxicity related to treatment. The 1\u2010year follow\u2010up report of the RADIOPARP Phase I trial, evaluating Olaparib associated with breast radiotherapy in TNBC patients, consequently demonstrated an excellent toxicity profile of this combination with few low\u2010grade adverse events.<\/jats:p>","DOI":"10.1002\/ijc.33737","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T13:03:41Z","timestamp":1626440621000},"page":"1828-1832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Combination of Olaparib with radiotherapy for triple\u2010negative breast cancers: One\u2010year toxicity report of the\n                    <scp>RADIOPARP<\/scp>\n                    Phase I trial"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-8110","authenticated-orcid":false,"given":"Pierre","family":"Loap","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology 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