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We studied the relationship between occupational insecticide use and risk of non\u2010Hodgkin lymphoma (NHL) by pooling data from nine case\u2010control studies participating in the InterLymph Consortium, including 7909 cases and 8644 controls from North America, the European Union and Australia. Insecticide use was coded using self\u2010report or expert assessment, for insecticide groups (eg, organophosphates, pyrethroids) and active ingredients (eg, malathion, permethrin). Associations with insecticides were estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CI) for all NHL and NHL subtypes, with adjustment for study site, demographic factors and use of other pesticides. Occupational insecticide use, overall, was not associated with risk of NHL. Use of organophosphate insecticides was associated with increased risk of all NHL and the subtype follicular lymphoma, and an association was found with diazinon, in particular (ever use: OR\u00a0=\u00a02.05, 95%CI: 1.24\u20103.37). The carbamate insecticide, carbaryl, was associated with risk of all NHL, and the strongest associations were found with T\u2010cell NHL for ever\u2010use (OR\u00a0=\u00a02.44, 95%CI: 1.13\u20105.28) and longer duration (&gt;8\u2009years vs never: OR\u00a0=\u00a02.90, 95%CI: 1.02\u20108.25). There was no association of NHL with other broad groups of insecticides, including organochlorines and pyrethroids, and some inverse associations were estimated in relation to historical DDT use. Our findings contribute to the totality of evidence available to help inform risk decisions by public health and regulatory agencies of importance given continued, widespread use of organophosphate and carbamate insecticides.<\/jats:p>","DOI":"10.1002\/ijc.33740","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T17:02:10Z","timestamp":1626454930000},"page":"1768-1786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Occupational insecticide exposure and risk of n<scp>on\u2010Hodgkin<\/scp> lymphoma: A pooled c<scp>ase\u2010control<\/scp> study from the <scp>InterLymph<\/scp> Consortium"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-2405","authenticated-orcid":false,"given":"Anneclaire J.","family":"De Roos","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, Dornsife School of Public Health Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah H.","family":"Schinasi","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dornsife School of Public Health Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Miligi","sequence":"additional","affiliation":[{"name":"Environmental and Occupational Epidemiology Branch, Institute for Cancer Research Prevention and Clinical Network (ISPRO)  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-178X","authenticated-orcid":false,"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota 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Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS)  Paris France"},{"name":"Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Casabonne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Research Program Institut Catal\u00e0 d'Oncologia (ICO)\/Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red: Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Fritschi","sequence":"additional","affiliation":[{"name":"Curtin University  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute  Betthesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dornsife School of Public Health Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Monnereau","sequence":"additional","affiliation":[{"name":"Epidemiology of Childhood and Adolescent Cancers Group, Inserm Center of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS)  Paris France"},{"name":"Registre des H\u00e9mopathies Malignes de la Gironde, Institut Bergoni\u00e9 University of Bordeaux, Inserm  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Piro","sequence":"additional","affiliation":[{"name":"Environmental and Occupational Epidemiology Branch, 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