{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:08Z","timestamp":1786977848391,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2011\u20100047"],"award-info":[{"award-number":["PR2011\u20100047"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population\u2010based cohort of childhood cancer survivors. A cohort of 26\u2009334 1\u2010year cancer survivors diagnosed before 20\u2009years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127\u2009531 age\u2010 and sex\u2010matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first\u2010time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29\u20101.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0\u201044.5), osteoporosis, RR 4.53 (3.28\u20106.27), fractures, RR 1.27 (1.20\u20101.34), osteochondropathies, RR 1.57 (1.28\u20101.92) and osteoarthrosis, RR 1.48 (1.28\u20101.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60\u2009years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high\u2010risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors.<\/jats:p>","DOI":"10.1002\/ijc.33741","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T02:41:20Z","timestamp":1626662480000},"page":"1863-1876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-5514","authenticated-orcid":false,"given":"Trausti","family":"Oskarsson","sequence":"first","affiliation":[{"name":"Department of Paediatric Oncology Astrid Lindgren Children's Hospital  Stockholm Sweden"},{"name":"Childhood Cancer Research Unit, Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Katrine","family":"Duun\u2010Henriksen","sequence":"additional","affiliation":[{"name":"Childhood Cancer Research Group Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bautz","sequence":"additional","affiliation":[{"name":"Childhood Cancer Research Group Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics, School of Medical Sciences \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Clinical Epidemiology Division Karolinska University Hospital, Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Epidemiology and Public Health University College London  London 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and Epidemiological Cancer Research, Finnish Cancer Registry  Helsinki Finland"},{"name":"Dana\u2010Farber Cancer Institute\/Boston Children's Cancer and Blood Disorders Center Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Pediatrics University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laufey","family":"Tryggvad\u00f3ttir","sequence":"additional","affiliation":[{"name":"The Icelandic Cancer Registry, Icelandic Cancer Society  Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-8148","authenticated-orcid":false,"given":"Anna S\u00e4llfors","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Division of Paediatric Oncology and Haematology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Clinical 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