{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:55:14Z","timestamp":1792670114708,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["111008"],"award-info":[{"award-number":["111008"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Small bowel cancer (SBC) is the malignancy with the highest standardized incidence ratio in Lynch syndrome (LS) patients. Of all SBCs, about 50% are duodenal cancers (DCs), therefore being accessible by esophago\u2010gastro\u2010duodenoscopy (EGD) for surveillance. We asked whether early detection of DC is possible for LS patients undergoing surveillance by EGD and if surveillance should be limited to specific subgroups. Data for LS patients with DC were retrieved from the registry of the German Consortium for Familial Intestinal Cancer. Patients undergoing active surveillance by EGDs (surveillance group) were compared to those who did not (nonsurveillance group) regarding tumor stage at diagnosis. Union for International Cancer Control stages I\u2010IIA were defined as early stage disease and IIB\u2010IV as advanced stage disease. Statistical analysis was performed using Fisher's exact test. Among 2015 patients with pathogenic variants in any mismatch\u2010repair\u2010gene, 47 patients with 49 DCs were identified. In 10% of cases, patients were under 35\u2009years at diagnosis; family and personal tumor history did not correlate with DC diagnosis. Pathogenic germline variants in\n                    <jats:italic>MSH6<\/jats:italic>\n                    ,\n                    <jats:italic>PMS2<\/jats:italic>\n                    or\n                    <jats:italic>EPCAM<\/jats:italic>\n                    were present in 10% of patients. Statistical analysis could be performed on 13 DC patients in the surveillance group and 14 in the nonsurveillance group. Early detection was possible for 71% of patients in the surveillance group and 29% of patients in the nonsurveillance group (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.021). Early detection of DC by EGD in LS patients is feasible regardless of family history, mutational status and should start no later than 25\u2009years of age.\n                  <\/jats:p>","DOI":"10.1002\/ijc.33753","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T12:48:49Z","timestamp":1627735729000},"page":"2052-2062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early detection of duodenal cancer by upper\n                    <scp>gastrointestinal<\/scp>\n                    \u2010endoscopy in Lynch syndrome"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-5683","authenticated-orcid":false,"given":"Deepak B.","family":"Vangala","sequence":"first","affiliation":[{"name":"Department of Medicine Knappschaftskrankenhaus, Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Molecular GI\u2010Oncology Ruhr\u2010University Bochum  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Medical Informatics, Statistics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolff","family":"Schmiegel","sequence":"additional","affiliation":[{"name":"Department of Medicine Knappschaftskrankenhaus, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pox","sequence":"additional","affiliation":[{"name":"Department of Medicine Knappschaftskrankenhaus, Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Department of Medicine St. Joseph\u2010Stift Bremen  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Schulmann","sequence":"additional","affiliation":[{"name":"Department of Medicine Knappschaftskrankenhaus, Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Praxis f\u00fcr H\u00e4matologie und Onkologie MVZ Arnsberg  Arnsberg 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