{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:12:37Z","timestamp":1788556357358,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007408","name":"Medical Center, University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is an important precursor of colorectal cancer. There is currently no study to determine the modifiable risk factors for colorectal adenomas, including body mass index (BMI) in Vietnam. We conducted an individually matched case\u2010control study of 1149 colorectal adenomas and 1145 controls in a large\u2010scale colorectal screening program involving 103\u2009542 individuals aged 40\u201075\u2009years old in Hanoi, Vietnam. Conditional logistic regression was used to evaluate the association between BMI and colorectal adenomas prevalence, after controlling for potential confounders. Overall, comparing to normal weight (ie, 18.5\u201022.9\u00a0kg\/m<jats:sup>2<\/jats:sup>), underweight (ie, BMI\u2009&lt;\u200918.5) was associated with a non\u2010statistically significant increased prevalence of colorectal adenomas (odd ratio [OR]\u00a0=\u00a01.29 and 95% confident interval [CI]: 0.88\u20101.87). This association became significant among male (OR\u00a0=\u00a01.98, 95% CI: 1.20\u20103.27), male who were ever smokers (OR\u00a0=\u00a02.59, 95% CI: 1.33\u20105.03), nonregular exercise (OR\u00a0=\u00a02.44, 95% CI: 1.26\u20104.73) and individuals with cardiometabolic disorders (OR\u00a0=\u00a03.46, 95% CI: 1.19\u201010.00). The association between underweight and colorectal adenomas did not vary by smoking status, drinking status, family history of cancer, adenomas types or cardiometabolic disorders. No association was observed among obese individuals (BMI\u2009\u2265\u200925). In the population with low prevalence of obesity, we found that the association between BMI and colorectal adenomas followed a reversed J\u2010shape that underweight was associated with increased prevalence. Further studies are, therefore, warranted to replicate our results and to investigate the biologic mechanism the effect of underweight on colorectal adenomas prevalence.<\/jats:p>","DOI":"10.1002\/ijc.33757","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T12:03:16Z","timestamp":1628078596000},"page":"1898-1909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between body mass index and colorectal adenomas: Findings from a <scp>case\u2010control<\/scp> study in Vietnam"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-1849","authenticated-orcid":false,"given":"Hung N.","family":"Luu","sequence":"first","affiliation":[{"name":"UPMC Hillman Cancer Center University of Pittsburgh Medical Center (UPMC)  Pittsburgh Pennsylvania USA"},{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  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Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyin","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt\u2010Ingram Cancer Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-5076","authenticated-orcid":false,"given":"Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt\u2010Ingram Cancer Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Stony Brook Cancer Center Stony Brooke University  Stony Brook New York 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