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Malaysia has achieved high\u2010coverage HPV vaccination since 2010, but coverage of the existing cytology\u2010based program remains low. Pilot studies found HPV self\u2010sampling was acceptable and effective, with high follow\u2010up rates when a digital registry was used, and recently the Malaysian Government announced plans for a national HPV\u2010based screening program. We therefore evaluated the impact of primary HPV screening with self\u2010collection in Malaysia in the context of Malaysia's existing vaccination program. We used the \u201c<jats:italic>Policy1\u2010Cervix<\/jats:italic>\u201d modeling platform to assess health outcomes, cost\u2010effectiveness, resource use and cervical cancer elimination timing (the year when cervical cancer rates reach four cases per 100\u2009000 women) of implementing primary HPV testing with self\u2010collection, assuming 70% routine\u2010screening coverage could be achieved. Based on available data, we assumed that compliance with follow\u2010up was 90% when a digital registry was used, but that compliance with follow\u2010up would be 50\u201075% without the use of a digital registry. We found that the current vaccination program would prevent 27\u2009000 to 32\u2009200 cervical cancer cases and 11\u2009700 to 14\u2009000 deaths by 2070. HPV testing with a digital registry was cost\u2010effective (CER\u00a0=\u00a0$US 6953\u20107549\u2009&lt;\u2009$US 11\u2009373[&lt;1\u00d7GDP per capita]) and could prevent an additional 15\u2009900 to 17\u2009800 cases and 9700 to 10\u2009600 deaths by 2070, expediting national elimination by 11 to 20\u2009years, to 2055 to 2059. If HPV screening were implemented without a digital registry, there would be 1800 to 4900 fewer deaths averted by 2070 and the program would be less cost\u2010effective. These results underline the importance of HPV testing as a key elimination pillar in Malaysia.<\/jats:p>","DOI":"10.1002\/ijc.33759","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T14:31:28Z","timestamp":1628346688000},"page":"1997-2009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The road to cervical cancer elimination in Malaysia: Evaluation of the impact and cost\u2010effectiveness of human papillomavirus screening with self\u2010collection and digital registry support"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7496-6746","authenticated-orcid":false,"given":"Adam","family":"Keane","sequence":"first","affiliation":[{"name":"Daffodil Centre The University of Sydney, A Joint Venture with Cancer Council NSW  Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu Wan","family":"Ng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate T.","family":"Simms","sequence":"additional","affiliation":[{"name":"Daffodil Centre The University of Sydney, A Joint Venture with Cancer Council NSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diep","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Daffodil Centre The University of Sydney, A Joint Venture with Cancer Council NSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Ling","family":"Woo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Saville","sequence":"additional","affiliation":[{"name":"VCS Foundation  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Canfell","sequence":"additional","affiliation":[{"name":"Daffodil Centre The University of Sydney, A Joint Venture with Cancer Council NSW  Sydney New South Wales Australia"},{"name":"Prince of Wales Clinical School  Faculty of Medicine, UNSW, Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"FerlayJ ErvikM LamF et al.Global Cancer Observatory: Cancer Today;2018.https:\/\/gco.iarc.fr\/today. 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