{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:25:45Z","timestamp":1788002745074,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01 CA87969"],"award-info":[{"award-number":["P01 CA87969"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA176726"],"award-info":[{"award-number":["U01 CA176726"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Emerging data suggest that exposures in early life may affect ovarian development and contribute to ovarian cancer risk. We evaluated the association between early life physical activity and risk of ovarian cancer in adulthood in two large prospective cohorts, the Nurses' Health Study (NHS) and NHSII. In total, analyses included 28\u2009232 NHS participants (followed from 2004 to 2016) and 56\u2009553 NHSII participants (followed from 1997 to 2017). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of ovarian cancer overall and by early life body mass index (BMI). Neither physical activity at ages 12\u201013, 14\u201017 or 18\u201022\u2009years nor average physical activity across these three periods was associated with ovarian cancer risk overall (\u226578 vs &lt;24 MET\u2010h\/wk, HRs\u00a0=\u00a01.34, 1.21, 1.08 and 1.24, respectively), or by categories of early life BMI (<jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009\u2265\u2009.44). No association was observed with the risk of high\u2010grade serous or poorly differentiated tumors or postmenopausal ovarian cancer. Overall, early life physical activity was not clearly related to ovarian cancer risk during adulthood.<\/jats:p>","DOI":"10.1002\/ijc.33760","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T16:17:15Z","timestamp":1629130635000},"page":"2045-2051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early life physical activity and risk of ovarian cancer in adulthood"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-7321","authenticated-orcid":false,"given":"Tianyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Jake\u2010Schoffman","sequence":"additional","affiliation":[{"name":"Department of Health Education and Behavior University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Vinci","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"},{"name":"Department of Oncologic Sciences University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C.","family":"Willett","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Nutrition Harvard School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-7046","authenticated-orcid":false,"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"},{"name":"Department of Oncologic Sciences University of South Florida  Tampa Florida USA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0067"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29834"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27952"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2524"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy546"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2018-0476"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0525"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2919-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116777"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-17-0309"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-020-00387-w"},{"key":"e_1_2_10_15_1","unstructured":"HoleshJE BassAN LordM. 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