{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T06:43:13Z","timestamp":1784443393222,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies highlight the need for a more active conditioning therapy in high\u2010risk or refractory and relapsed lymphomas. Our preclinical research shows that histone deacetylase inhibitors, such as either vorinostat or chidamide, sensitize lymphoma cells to the cytotoxic combination of cladribine, gemcitabine and busulfan, leading to cell apoptosis. To evaluate the efficacy of this chidamide\u2010cladribine\u2010gemcitabine\u2010busulfan (ChiCGB) combination as a new conditioning therapy, we conducted a Phase II trial, as described here. Patients with high\u2010risk, relapsed\/refractory lymphomas received ChiCGB as conditioning therapy, after transplantation with autologous peripheral stem cells. The sample comprised 105 patients in total: 60 with B\u2010cell non\u2010Hodgkin lymphomas (B\u2010NHL) and 45 with T\u2010cell or natural killer\/T\u2010cell lymphoma (NK\/T). All patients eventually achieved full hematopoietic recovery. Neutrophils and platelets were engrafted at a median of 10\u2009days (8\u201014) and 13\u2009days (8\u201038), respectively. There was no transplant\u2010related mortality within 100\u2009days of transplant. Neutropenic fever, mucositis and atopic dermatitis were the observed nonhematologic toxicities. At a median follow\u2010up of 35.4\u00a0months, 80.6% of the patients presented with no tumor progression, and the overall survival (OS) reached as high as 86.1%. Concerning the OS rate, 94.5% of patients with B\u2010NHL and 75.4% of patients with T\u2010cell or NK\/T lymphomas survived. These findings demonstrate the safety and validity of the proposed combined therapy for high\u2010risk and refractory\/relapsed lymphomas. Our study was registered on the Clinical Trial Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>, NCT03151876).<\/jats:p>","DOI":"10.1002\/ijc.33761","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T16:05:52Z","timestamp":1629129952000},"page":"2075-2082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A new conditioning regimen with chidamide, cladribine, gemcitabine and busulfan significantly improve the outcome of high\u2010risk or relapsed\/refractory <scp>non\u2010Hodgkin<\/scp>'s lymphomas"],"prefix":"10.1002","volume":"149","author":[{"given":"Jie","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-5551","authenticated-orcid":false,"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Hematology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92411-L"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08938-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332305"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301077"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1618"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.2980"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578963"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.02.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.03.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1847-5"},{"key":"e_1_2_10_12_1","unstructured":"NCI. 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