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Herein, we report the induction of adipocyte dedifferentiation by OvCa cells and pro\u2010tumorigenic effects of resulted adipocyte\u2010derived fibroblasts. We confirmed that malignant ascites promoted the dedifferentiation of the primary human adipocytes obtained from surgical omental specimen into omental adipocyte\u2010derived fibroblast (O\u2010ADF) that possess both mesenchymal stem cell and myofibroblast\u2010like features. This promotion of dedifferentiation by malignant ascites was blocked by addition of Wnt signaling inhibitor. The effects of dedifferentiated adipocytes in proliferation and migration of OvCa cells were analyzed with in\u2009vitro coculturing experimental models and in\u2009vivo mice model, and we demonstrated that OvCa cell lines showed enhanced proliferative characteristics, as well as increased migratory abilities upon coculturing with O\u2010ADF. Additionally, exogenous transforming growth factor\u2010\u03b21 augmented desmoplastic morphological change of O\u2010ADF, leading to higher proliferative ability. Our results suggest that OvCa cells promote dedifferentiation of peritoneal adipocytes by activating Wnt\/\u03b2\u2010catenin signaling, and generated O\u2010ADFs exhibit pro\u2010tumoral hallmarks.<\/jats:p>","DOI":"10.1002\/ijc.33770","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T17:18:22Z","timestamp":1630516702000},"page":"1961-1972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pro\u2010tumoral behavior of omental adipocyte\u2010derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer"],"prefix":"10.1002","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4596-2177","authenticated-orcid":false,"given":"Shohei","family":"Iyoshi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Spemann Graduate School of Biology and 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