{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:11:10Z","timestamp":1787508670205,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Body weight loss is frequently regarded as negatively related to outcomes in patients with malignancies. This retrospective analysis of the FIRE\u20103 study evaluated the evolution of body weight in patients with metastatic colorectal cancer (mCRC). FIRE\u20103 evaluated first\u2010line FOLFIRI (folinic acid, fluorouracil and irinotecan) plus cetuximab or bevacizumab in mCRC patients with\n                    <jats:italic>RAS<\/jats:italic>\n                    \u2010WT tumors (ie, wild\u2010type in\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>NRAS<\/jats:italic>\n                    exons 2\u20104). The prognostic and predictive relevance of early weight loss (EWL) regarding patient outcomes and treatment side effects were evaluated. Retrospective data on body weight during first 6\u00a0months of treatment were evaluated (N\u00a0=\u00a0326). To correlate with efficacy endpoints and treatment side effects, patients were grouped according to clinically significant EWL \u22655% and &lt;5% at Month\u00a03. Age constituted the only significant predictor of EWL following a linear relationship with the corresponding log odds ratio (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.016). EWL was significantly associated with the incident frequencies of diarrhea, edema, fatigue, nausea and vomiting. Further, a multivariate analysis revealed EWL to be an independent negative prognostic factor for overall survival (32.4 vs 21.1\u00a0months; hazard ratio [HR]: 1.64; 95% confidence interval [CI]\u00a0=\u00a01.13\u20102.38;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0098) and progression\u2010free survival (11.8 vs 9.0\u00a0months; HR: 1.72; 95%\u00a0CI\u00a0=\u00a01.18\u20102.5;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0048). In conclusion, EWL during systemic treatment against mCRC is significantly associated with patient age. Patients exhibiting EWL had worse survival and higher frequencies of adverse events. Early preventative measures targeted at weight maintenance should be evaluated, especially in elderly patients being at highest risk of EWL.\n                  <\/jats:p>","DOI":"10.1002\/ijc.33775","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T06:46:16Z","timestamp":1629873976000},"page":"112-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Early weight loss is an independent risk factor for shorter survival and increased side effects in patients with metastatic colorectal cancer undergoing first\u2010line treatment within the randomized Phase\u00a0\n                    <scp>III<\/scp>\n                    trial\n                    <scp>FIRE<\/scp>\n                    \u20103 (\n                    <scp>AIO KRK<\/scp>\n                    \u20100306)"],"prefix":"10.1002","volume":"150","author":[{"given":"Lian","family":"Liu","sequence":"first","affiliation":[{"name":"Comprehensive Cancer Center University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Tonya","family":"Erickson","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Ricard","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig Fischer","family":"von Weikersthal","sequence":"additional","affiliation":[{"name":"Gesundheitszentrum St Marien  Amberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Lerch","sequence":"additional","affiliation":[{"name":"Klinik und 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