{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:08:39Z","timestamp":1767136119239,"version":"build-2238731810"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["19\u2010B\u20100077"],"award-info":[{"award-number":["19\u2010B\u20100077"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Worldwide, colorectal cancer is the second most common cancer and third cause of cancer death in women. Estrogen exposure has been inversely associated with colorectal cancer. Oophorectomy reduces circulating estrogen, but the effect on colorectal cancer remains uncertain. The aim of this study was to examine the association between unilateral and bilateral oophorectomy and subsequent risk of colorectal cancer, and whether this association varied by menopausal status at time of oophorectomy, use of hormone replacement therapy (HRT) at baseline, hysterectomy and baseline body mass index (BMI). The study included 25\u2009698 female nurses (aged \u226545\u2009years) participating in the Danish Nurse Cohort. Nurses were followed from baseline until date of colorectal cancer, death, emigration or end of follow\u2010up at December 31, 2018, whichever came first. We examined the association between oophorectomy and colorectal cancer (all ages and stratified by menopausal status). The potential modifying effects of hysterectomy, HRT use at baseline and BMI were investigated. During 542\u2009140 person\u2010years of follow\u2010up, 863 (3.4%) nurses were diagnosed with colorectal cancer. Bilateral oophorectomy was associated with a 79% increased colorectal cancer rate, adjusted rate ratio (aRR) (95% confidence interval [CI]): 1.79 (1.33\u20102.42). Effect estimates following unilateral oophorectomy also showed higher rate of colorectal cancer, although less pronounced and nonstatistically significant (aRR) (95%\u00a0CI): 1.25 (0.86\u20101.82). Similar results were seen when stratifying by menopausal status. The association was not modified by baseline HRT use, hysterectomy or BMI. Oophorectomy was associated with increased rate of colorectal cancer, with highest rates among women with bilateral oophorectomy.<\/jats:p>","DOI":"10.1002\/ijc.33776","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T13:19:20Z","timestamp":1630070360000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bilateral oophorectomy and rate of colorectal cancer: A prospective cohort study"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-7268","authenticated-orcid":false,"given":"Trine","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Therming J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Christensen","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis, Danish Cancer Society  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Katrine","family":"Duun\u2010Henriksen","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis, Danish Cancer Society  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e6rke","family":"Priskorn","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Kildev\u00e6ld Simonsen","sequence":"additional","affiliation":[{"name":"Diakonissestiftelsen and Parker Institute, Frederiksberg Hospital  Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-4565","authenticated-orcid":false,"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis, Danish Cancer Society  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Jovanovic Andersen","sequence":"additional","affiliation":[{"name":"Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"Centre for Epidemiological Research Nyk\u00f8bing F Hospital  Nyk\u00f8bing F Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira V.","family":"Br\u00e4uner","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_11_3_1","unstructured":"Danckert B Ferlay J Engholm G Hansen HL Johannesen TB Khan S K\u00f8tlum JE \u00d3lafsd\u00f3ttir E Schmidt LKH Virtanen A Storm HH. 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