{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:25:02Z","timestamp":1792297502892,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polygenic risk scores (PRS) for disease risk stratification show great promise for application in general populations, but most are based on data from individuals of White European origin. We assessed two well validated PRS (SNP18, SNP143) in the Predicting\u2010Risk\u2010of\u2010Cancer\u2010At\u2010Screening (PROCAS) study in North\u2010West England for breast cancer prediction based on ethnicity. Overall, 9475 women without breast cancer at study entry, including 645 who subsequently developed invasive breast cancer or ductal carcinoma in situ provided DNA. All were genotyped for SNP18 and a subset of 1868 controls were genotyped for SNP143. For White Europeans both PRS discriminated well between individuals with and without cancer. For n\u00a0=\u00a0395 Black (n\u00a0=\u00a0112), Asian (n\u00a0=\u00a0119), mixed (n\u00a0=\u00a044) or Jewish (n\u00a0=\u00a0120) women without cancer both PRS overestimated breast cancer risk, being most marked for women of Black and Jewish origin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). SNP143 resulted in a potential mean 40% breast cancer risk overestimation in the combined group of non\u2010White\/non\u2010European origin. SNP\u2010PRS that has been normalized based on White European ethnicity for breast cancer should not be used to predict risk in women of other ethnicities. There is an urgent need to develop PRS specific for other ethnicities, in order to widen access of this technology.<\/jats:p>","DOI":"10.1002\/ijc.33782","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T14:43:50Z","timestamp":1630334630000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The importance of ethnicity: Are breast cancer polygenic risk scores ready for women who are not of White European origin?"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-5784","authenticated-orcid":false,"given":"D. Gareth","family":"Evans","sequence":"first","affiliation":[{"name":"Nightingale\/Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Manchester Breast Centre, Manchester Cancer Research Centre The Christie Hospital  Manchester UK"},{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"},{"name":"Clinical Genetics Service, Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke M.","family":"van Veen","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Byers","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Howell","sequence":"additional","affiliation":[{"name":"Nightingale\/Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Manchester Breast Centre, Manchester Cancer Research Centre The Christie Hospital  Manchester UK"},{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha J.","family":"Howell","sequence":"additional","affiliation":[{"name":"Nightingale\/Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Manchester Breast Centre, Manchester Cancer Research Centre The Christie Hospital  Manchester UK"},{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Harkness","sequence":"additional","affiliation":[{"name":"Nightingale\/Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Informatics, Imaging &amp; Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-4357","authenticated-orcid":false,"given":"Adam","family":"Brentnall","sequence":"additional","affiliation":[{"name":"Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-7512","authenticated-orcid":false,"given":"Jack","family":"Cuzick","sequence":"additional","affiliation":[{"name":"Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Clinical Genetics Service, Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05887"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.11.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17680-w"},{"key":"e_1_2_10_5_1","article-title":"Development and validation of a clinical polygenic risk score to predict breast cancer risk","volume":"4","author":"Hughes E","year":"2020","journal-title":"JCO Precis Oncol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4881"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32541"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-104125"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4638-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab050"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-017-0035-5"},{"key":"e_1_2_10_12_1","unstructured":"https:\/\/mypebs.eu\/the-project\/.Accessed March 1 2021."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz174"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0682-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0379-x"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T19:11:29Z","timestamp":1692299489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ijc.33782"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33782","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]},"assertion":[{"value":"2021-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}