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In an ideal world, screening would only be directed to the small proportion of the population that might potentially benefit. Risk\u2010based screening can be seen as a first step towards this ideal world, by redistributing screening resources from low\u2010risk to high\u2010risk individuals. In theory, this should result in scarce resources being used in individuals who benefit most, while intensity of screening is reduced in individuals who benefit less, hence improving the benefit\u2010harm ratio among all invitees. Available strategies that have been proposed for risk\u2010based CRC screening include using information on age, sex, prior screening history, lifestyle and\/or genetic information. Implementation of risk\u2010based screening requires careful consideration of reliable risk prediction models, participation with screening and informed decision\u2010making. While it is important to recognise the limitations of current approaches, available evidence suggests that it might be feasible to start planning the introduction of tailored strategies within screening programmes. Implementing risk\u2010based screening based on age, sex and prior screening history alone would already represent a substantial improvement over current uniform screening approaches. We propose that it is time that screening programmes start there and continue striving towards more comprehensive approaches embedding primary prevention as an effective approach to lower risk for everyone.<\/jats:p>","DOI":"10.1002\/ijc.33784","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T14:39:57Z","timestamp":1630334397000},"page":"397-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Risk\u2010stratified strategies in population screening for colorectal cancer"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-2753","authenticated-orcid":false,"given":"Iris","family":"Lansdorp\u2010Vogelaar","sequence":"first","affiliation":[{"name":"Department of Public Health Erasmus University Medical Centre  Rotterdam The 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