{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:12:09Z","timestamp":1747149129403,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000521","name":"Canadian Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Head trauma in early childhood has been hypothesized as a potential risk factor for childhood brain tumours (CBTs). However, head trauma has not been extensively studied in the context of CBTs and existing studies have yielded conflicting results. A population\u2010based and hospital\u2010based case\u2010control study of children 0 to 15\u2009years with newly diagnosed CBTs from 1997 to 2003 recruited across Ontario through paediatric oncology centres was conducted. Controls were frequency\u2010matched with cases by age, sex and geographical region. The association was assessed based on multivariable logistic regressions, accounting for child's age, sex, ethnicity, highest level of maternal education and maternal pack\u2010years of smoking during the pregnancy. Analyses were conducted separately based on age of first head trauma, sex and histology. A latency period analysis was conducted. Overall, based on 280 cases and 919 controls, CBTs were not significantly associated with previous history of head trauma (OR 1.34, 95% CI 0.96, 1.86), head trauma severity, number of head injuries, or head or neck X\u2010rays or computed tomography (CT) examinations. Results were consistent across sexes and histological subtypes. However, head trauma within the first year of life was significantly associated with CBTs (OR 2.00, 95% CI 1.01, 3.98), but the association diminished when adjusted for X\u2010ray or CT occurring during the same time period (OR 1.62, 95% CI 0.75, 3.49), albeit limited sample size. Overall, no association was observed between head trauma and CBTs among all children, while head trauma occurring within first year of life may warrant further investigation in future research.<\/jats:p>","DOI":"10.1002\/ijc.33805","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T17:03:50Z","timestamp":1631639030000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Childhood head trauma and the risk of childhood brain tumours: A case\u2010control study in Ontario, Canada"],"prefix":"10.1002","volume":"150","author":[{"given":"Sierra","family":"Cheng","sequence":"first","affiliation":[{"name":"Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-7732","authenticated-orcid":false,"given":"M. Catherine","family":"Brown","sequence":"additional","affiliation":[{"name":"Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health  Toronto Ontario Canada"},{"name":"Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamad","family":"Al\u2010Sawaihey","sequence":"additional","affiliation":[{"name":"Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Rutka","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Paediatric Laboratory Medicine The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Elizabeth","family":"Cairney","sequence":"additional","affiliation":[{"name":"Children's Hospital London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrianna","family":"Ranger","sequence":"additional","affiliation":[{"name":"Children's Hospital London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Fleming","sequence":"additional","affiliation":[{"name":"McMaster Children's Hospital Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Johnston","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Pediatric Oncology Group of Ontario  Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Malkin","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-7496","authenticated-orcid":false,"given":"Rayjean J.","family":"Hung","sequence":"additional","affiliation":[{"name":"Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_10_3_1","unstructured":"Canadian Cancer Statistics Advisory Committee.Canadian cancer statistics 2019 [Internet]. 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