{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:19:50Z","timestamp":1780654790428,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Camrelizumab (a humanized high\u2010affinity IgG4 mAb against programmed death\u2010l) showed potent antitumor activity, well tolerance and controllable safety in patients with relapsed or refractory classical Hodgkin lymphoma (r\/r cHL), based on the primary analysis of a Phase\u00a02 study. Here, we present the extended follow\u2010up outcomes. Seventy\u2010five patients who had failed to achieve a remission or experienced progression after autologous stem cell transplantation or had received at least two lines of systemic chemotherapies were enrolled to receive camrelizumab 200\u2009mg every 2\u2009weeks. With a median follow\u2010up of 36.2\u2009months (range, 7.2\u201038.1), objective response rate per independent central review was 76.0% (95% confidence interval [CI],\u00a064.7\u201085.1). Among the 57 responders, 31 (54.4%) had ongoing responses. Median duration of response was 31.7\u00a0months (95% CI,\u00a016.7\u2010not reached). Median progression\u2010free survival was 22.5\u00a0months (95%\u00a0CI, 14.7\u2010not reached). Thirty\u2010six\u2010month overall survival rate was 82.7% (95% CI, 72.0\u201089.5). Reactive capillary endothelial proliferation (RCEP) occurred in 97.3% of patients (73\/75), but all RCEP were Grade 1 or 2 in severity and 67.1% of these patients (49\/73) achieved complete resolution. Occurrence of new RCEP lesions was rare (8\/42 [19.0%] at 12\u2009months; 2\/32 [6.3%] at 24\u2009months). No treatment\u2010related deaths occurred, and no new toxicities were reported. With extended follow\u2010up, camrelizumab monotherapy continues to provide a robust and durable response, long survival and manageable safety in r\/r cHL patients.<\/jats:p>","DOI":"10.1002\/ijc.33852","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T12:46:53Z","timestamp":1634820413000},"page":"984-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Camrelizumab for relapsed or refractory classical Hodgkin lymphoma: Extended follow\u2010up of the multicenter, single\u2010arm, Phase 2 study"],"prefix":"10.1002","volume":"150","author":[{"given":"Jianqiu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Oncology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research &amp; The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junning","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Lymphatic Comprehensive Internal Medicine Ward Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Lymphoma Clinic, Blood Diseases Hospital Chinese Academy of Medical Sciences  Tianjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Cancer Hospital Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8478-1021","authenticated-orcid":false,"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Hengrui Pharmaceuticals Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Statistics and Programming Jiangsu Hengrui Pharmaceuticals Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research &amp; The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-2547","authenticated-orcid":false,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2542"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282780"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.4482"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-770719"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2016.1121812"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.1316"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1680"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001367"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.0793"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000324"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3467"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050646"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0545-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"SuH SongY JiangW et al. 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