{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:29Z","timestamp":1786977929854,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001593","name":"Irish Cancer Society","doi-asserted-by":"publisher","award":["HIC15MOL"],"award-info":[{"award-number":["HIC15MOL"]}],"id":[{"id":"10.13039\/501100001593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Treatment advances over the past five decades have resulted in significant improvements in survival from childhood cancer. Although survival rates are relatively high, social disparities in outcomes have been sometimes observed. In a population\u2010based study, we investigated social inequalities by sex and deprivation in treatment receipt in childhood cancer in Ireland. Cancers incident in people aged 0 to 19 during 1994 to 2012 and treatments received were abstracted from the National Cancer Registry Ireland. Multivariable modified Poisson regression with robust error variance (adjusting for age, and year) was used to assess associations between sex and deprivation category of area of residence at diagnosis and receipt of cancer\u2010directed surgery, chemotherapy or radiotherapy. Three thousand seven hundred and four childhood cancers were included. Girls were significantly less likely than boys to receive radiotherapy for leukemia overall (relative risk [RR]\u00a0=\u00a00.70; 95% confidence interval [CI]\u00a0=\u00a00.50\u20100.98), and acute lymphoblastic leukemia specifically (RR\u00a0=\u00a00.54; 95%\u00a0CI\u00a0=\u00a00.36\u20100.79), and surgery for central nervous system (CNS) overall (RR\u00a0=\u00a00.83; 95%\u00a0CI\u00a0=\u00a00.74\u20100.93) and other CNS (RR\u00a0=\u00a00.76; 95%\u00a0CI\u00a0=\u00a00.60\u20100.96). Girls were slightly less likely to receive chemotherapy for non\u2010Hodgkin lymphoma and surgery for Hodgkin lymphoma (HL), but these results were not statistically significant. Children residing in more deprived areas were significantly less likely to receive chemotherapy for acute myeloid leukemia or surgery for lymphoma overall and HL, but more likely to receive chemotherapy for medulloblastoma. These results may suggest social inequalities in treatment receipt for childhood cancers. Further research is warranted to explore whether similar patterns are evident in other childhood cancer populations and to better understand the reasons for the findings.<\/jats:p>","DOI":"10.1002\/ijc.33856","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T13:04:57Z","timestamp":1635339897000},"page":"941-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Social inequalities in treatment receipt for childhood cancers in Ireland: A population\u2010based analysis"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7353-8931","authenticated-orcid":false,"given":"Michal","family":"Molcho","sequence":"first","affiliation":[{"name":"School of Education NUI Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"School of Education NUI Galway  Galway Ireland"},{"name":"Division of Undergraduate Education UC Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"National Cancer Registry Ireland  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick","family":"Skinner","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Haematology\/Oncology Great North Children's Hospital  Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Wolfson Childhood Cancer Research Centre  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Sharp","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University Centre for Cancer  Newcastle upon Tyne 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