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Pazopanib, an oral tyrosine kinase inhibitor, selectively inhibits VEGFR\u20101, \u20102 and\u00a0\u20103, c\u2010kit and PDGF\u2010R resulting in inhibition of angiogenesis. This open\u2010label randomized phase II trial (2:1) investigated the efficacy of combining pazopanib with FLO (5\u2010fluorouracil, oxaliplatin) vs FLO alone (internal control arm) as first\u2010line treatment in patients with advanced adenocarcinoma of the stomach and gastroesophageal junction (GEJ). Eighty\u2010seven patients were randomized and 78 patients were eligible and evaluable (PaFLO arm 51 patients, FLO arm 27 patients). The PFS rate at 6 months (primary endpoint) was 34% in the PaFLO arm vs 30% in the FLO arm. Comparing PaFLO with FLO median PFS was 4.66 months (95% confidence interval [CI] 2.87\u20106.46) vs 4.47 months (95% CI 1.79\u20107.14) (95% CI, hazard ratio [HR] 0.96 (0.60\u20101.55), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.882 [exploratory]); median OS was 10.19 months (95% CI 5.46\u201014.92) vs 7.33 months (95% CI 4.93\u20109.73), (95% CI HR 1.01 [0.62\u20101.65], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.953, exploratory), disease control rate was 72% vs 59%. PaFLO was well tolerable, toxicities were slightly higher in the PaFLO arm. Major adverse events were loss of appetite, nausea, fatigue, diarrhea, neutropenia and thrombocytopenia. Adding pazopanib to chemotherapy shows signs of efficacy but no major improvement in this randomized phase 2 trial. The PFS at 6\u00a0months in both arms was lower than expected from the literature. Biomarkers identifying subgroups who benefit and novel combinations are needed. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT01503372.<\/jats:p>","DOI":"10.1002\/ijc.33864","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T14:38:24Z","timestamp":1636209504000},"page":"1007-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pazopanib with <scp>5\u2010FU<\/scp> and oxaliplatin as first line therapy in advanced gastric cancer: A randomized <scp>phase\u2010II<\/scp> study\u2014The <scp>PaFLO<\/scp> trial. A study of the Arbeitsgemeinschaft Internistische Onkologie <scp>AIO\u2010STO<\/scp>\u20100510"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-6449","authenticated-orcid":false,"given":"Anica","family":"H\u00f6gner","sequence":"first","affiliation":[{"name":"Medizinische Klinik m.S. H\u00e4matologie, Onkologie und Tumorimmunologie Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah\u2010Eddin","family":"Al\u2010Batran","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens T.","family":"Siveke","sequence":"additional","affiliation":[{"name":"II. 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