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The median age was 59 (min 16\u2010max 98) years with male preponderance (77.9%). The predominant cohort received short\u2010course ICI therapy; the median number of cycles was 5 (95% confidence interval [CI] 1\u201027), and the median duration of therapy was 3 (95% CI 0.5\u201013) months. ICIs were used commonly in the second and third line setting in our study (66.4%, n\u00a0=\u00a0671). Objective response rate (complete or partial response) was documented in 254 (25.1%) of the patients, 202 (20.0%) had stable disease, and 374 (37.0%) had progressive disease. The clinical benefit rate was present in 456 (45.1%). Among the patients whom ICI was stopped (n\u00a0=\u00a0906), the most common reason for cessation of ICI was disease progression (616, 68.0%) followed by logistic reasons like financial constraints (234, 25.82%). With a median follow\u2010up of 14.1 (95% CI 12.9\u201015.3) months, there were 616 events of progression and 443 events of death, and the median progression free survival and overall survival were 6.4 (95% CI 5.5\u20107.3) and 13.6 (95% CI 11.6\u201015.7) months, respectively, in the overall cohort. Among the immune\u2010related adverse events, autoimmune pneumonitis (29, 3.8%) and thyroiditis (24, 2.4%) were common. Real\u2010world multicentric Indian data predominantly with short\u2010course ICI therapy have comparable efficacy\/safety to international literature with standard ICI therapy.<\/jats:p>","DOI":"10.1002\/ijc.33868","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T13:29:32Z","timestamp":1636464572000},"page":"1045-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The clinical utility and safety of short\u2010course immune checkpoint inhibitors in multiple tumours\u2014A real\u2010world multicentric study from India"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-1262","authenticated-orcid":false,"given":"George","family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Tata Memorial Centre Mumbai 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