{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:16:11Z","timestamp":1789924571215,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous studies have reported inconsistent findings concerning the impact of statin use on cancer prevention. Our study examined the association between statin use and cancer incidence and mortality related to breast and gynecologic cancers in South Korea. A population\u2010based cohort study was conducted using the National Health Insurance claims database. Women aged 45 to 70\u2009years old who had taken statins for at least 6\u2009months were compared to statin non\u2010users of the same age from January 2005 to June 2013. The primary outcomes were cancer incidence and mortality related to breast cancer, total gynecologic cancers, cervix uteri cancer and ovarian cancer. Cox proportional hazards regression was conducted to calculate the adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs). Out of 587\u2009705 women, there were 3591 cases of breast cancer, 2239 cases of gynecologic cancers and 565 breast and total gynecologic cancer deaths during 7.6 person\u2010years. The aHRs for the association between the risk of each cancer and statin use were 0.88 (95% CI 0.79\u20100.97) for breast cancer and 0.83 (95% CI 0.67\u20100.99) for cervix uteri cancer. Statin use was associated with decreased breast cancer mortality (HR\u00a0=\u00a00.65, 95% CI 0.43\u20100.99) and total gynecologic cancer mortality (HR\u00a0=\u00a00.70, 95% CI 0.50\u20100.98). A dose\u2010response relationship was only found for all\u2010cancer mortality. Statin use for at least 6\u2009months was significantly associated with a lower risk of breast and cervix uteri cancer incidence, and with lower mortality of breast and gynecologic cancers. Further research on these associations will be needed.<\/jats:p>","DOI":"10.1002\/ijc.33869","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T08:30:11Z","timestamp":1636446611000},"page":"1156-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Statin use and incidence and mortality of breast and gynecology cancer: A cohort study using the National Health Insurance claims database"],"prefix":"10.1002","volume":"150","author":[{"given":"Dong\u2010Sook","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Research Health Insurance Review &amp; Assessment Service  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-7466","authenticated-orcid":false,"given":"Hyeong Sik","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine, 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