{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:55:19Z","timestamp":1784944519454,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Self\u2010sampling provides a powerful means to engage women in cervical screening. In the original Papillomavirus Dumfries and Galloway study (PaVDaG), we demonstrated cross\u2010sectional similarity of high\u2010risk human papillomavirus (Hr\u2010HPV) testing on self\u2010taken vaginal vs clinician\u2010taken samples for the detection of cervical intraepithelial neoplasia 2 or worse (CIN2+). Few data exist on the longitudinal performance of self\u2010sampling; we present longitudinal outcomes of PaVDaG. Routinely screened women provided a self\u2010taken and a clinician\u2010collected sample. Ninety\u2010one percent of 5136 women from the original cohort completed a further screening round. Sensitivity, specificity, positive predictive value and complement of the negative predictive value of the Hr\u2010HPV test on self\u2010samples for detection of CIN2+ and CIN3+ up\u2010to 5\u2009years after testing were determined. Additionally, clinical accuracy of Hr\u2010HPV testing on vaginal and clinician\u2010collected samples was assessed. A total of 183 CIN2+ and 102 CIN3+ lesions were diagnosed during follow\u2010up. Risk of CIN2+ and CIN3+ following an Hr\u2010HPV negative self\u2010sample was 0.6% and 0.2%, respectively, for up to 5\u2009years after testing. The relative sensitivity for CIN3+ and specificity for \u2264CIN1 of Hr\u2010HPV testing on self\u2010taken specimens was slightly lower vs clinician\u2010collected samples: 0.95 (95% CI: 0.90\u20100.99; <jats:italic>P<\/jats:italic><jats:sup>McN<\/jats:sup> = .0625) and 0.98 (95% CI: 0.95\u20101.00; <jats:italic>P<\/jats:italic><jats:sup>McN<\/jats:sup>\u2009=\u2009&lt;.0000), respectively. The low risk of CIN2+ in women with Hr\u2010HPV\u2014self\u2010sample(s) suggests, that the 3 to 5\u2010year recall interval implemented in several cervical screening settings, based on clinician\u2010taken samples, may be safe for self\u2010samples. Future assessment will show if \u201cuniversal\u201d 5\u2010year screening is appropriate for programs based on self\u2010sampling.<\/jats:p>","DOI":"10.1002\/ijc.33888","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T06:03:40Z","timestamp":1638338620000},"page":"1350-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Self\u2010sampling as the principal modality for population based cervical screening: Five\u2010year follow\u2010up of the <scp>PaVDaG<\/scp> study"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-1536","authenticated-orcid":false,"given":"Grazyna A.","family":"Stanczuk","sequence":"first","affiliation":[{"name":"Department of Research and Development Dumfries and Galloway Royal Infirmary  Dumfries UK"},{"name":"Global Health Academy University of Edinburgh  Edinburgh 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