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We prospectively examined the relationship between HBV infection and new\u2010onset GI cancers among 93\u2009402 participants. Cox proportional hazards regression models, subgroup analyses and competing risk analyses were used to evaluate the association between HBV infection and the risk of new\u2010onset GI cancers. During a median follow\u2010up of 13.02\u2009years, 1791 incident GI cancer cases were diagnosed. Compared to HBsAg seronegative participants, a significant positive association between HBV infection and GI cancers was observed in the multivariate\u2010adjusted models (HR 5.59, 95% CI: 4.84\u20106.45). In the site\u2010specific analyses, participants with HBsAg seropositive exhibited an increased risk of liver cancer (HR\u00a0=\u00a021.56, 95% CI: 17.32\u201026.85), gallbladder or extrahepatic bile duct cancer (HR\u00a0=\u00a014.89, 95% CI: 10.36\u201021.41), colorectal cancer (HR\u00a0=\u00a01.75, 95% CI: 1.15\u20102.96) and pancreatic cancer (HR\u00a0=\u00a01.86, 95% CI: 1.10\u20103.99). After taking death as the competing risk event, the associations of HBV infection with the risk of these cancers were attenuated but remained significant both in the cause\u2010specific hazards models, the subdistribution proportional hazards models and sensitivity analyses. Our study suggests that HBV infection is associated with the elevated risk of liver cancer and extrahepatic cancer including gallbladder or extrahepatic bile duct, pancreatic and colorectal cancer among adults in Northern China.<\/jats:p>","DOI":"10.1002\/ijc.33891","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T15:25:58Z","timestamp":1638458758000},"page":"1018-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: A prospective cohort study"],"prefix":"10.1002","volume":"150","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Department of Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  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for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Department of Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"},{"name":"Key Laboratory of Cancer FSMP for State Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-3935","authenticated-orcid":false,"given":"Mengmeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Department of Clinical Nutrition 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