{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:19:38Z","timestamp":1789427978383,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009925","name":"Villadsen Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increases observed in incidence and survival of oropharyngeal squamous cell carcinoma (OPSCC) have been attributed to human papillomavirus (HPV) infection, but the survival\u2010impact of specific genotypes is poorly understood. We investigated the potential influence of HPV genotypes on survival in HPV\u2010positive (HPV+) OPSCC. All patients with HPV+\/p16+ OPSCC and available genotype data within the period 2011 to 2017 in Eastern Denmark were included. Descriptive statistics on clinical and tumor data, as well as overall survival (OS) and recurrence\u2010free survival (RFS) with Cox hazard models and Kaplan\u2010Meier plots were performed. Overall, 769 HPV+\/p16+ OPSCC patients were included of which genotype HPV16 accounted for 86% (n\u00a0=\u00a0662). Compared to high\u2010risk non\u2010HPV16 genotypes (HR non\u2010HPV16), HPV16 patients were younger at diagnosis (median years, 60 vs 64), had a higher male to female ratio (3.7:1 vs 2.1:1), and lower performance scores of \u22641 (90%, n\u00a0=\u00a0559, vs 81%, n\u00a0=\u00a074). Regarding 5\u2010year OS and RFS, no difference was observed between HPV16 and HR non\u2010HPV16 patients. Subgrouping the HR non\u2010HPV16 group into HPV33 (n\u00a0=\u00a057), HPV35 (n\u00a0=\u00a026) and \u201cother genotypes\u201d (n\u00a0=\u00a024) a significantly worse OS in the \u201cother genotypes\u201d group (hazard rate: 2.33, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.027) was shown. With similar survival results between HPV16 and non\u2010HPV16 genotypes, genotyping in OPSCC is interesting from an epidemiological point of view as well as in vaccination programs, but not a necessary addition in prognostication of HPV+\/p16+ OPSCC.<\/jats:p>","DOI":"10.1002\/ijc.33893","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T11:11:21Z","timestamp":1639221081000},"page":"1174-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of specific high\u2010risk human papillomavirus genotypes on survival in oropharyngeal cancer"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-8003","authenticated-orcid":false,"given":"Martin","family":"Garset\u2010Zamani","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery and Audiology, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda F.","family":"Carlander","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery and Audiology, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine K.","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery and Audiology, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Friborg","sequence":"additional","affiliation":[{"name":"Department of Oncology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery and Audiology, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx304"},{"key":"e_1_2_11_4_1","first-page":"1","article-title":"Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000\u20102016 in the Stockholm region and Sweden","volume":"41","author":"Haeggblom L","year":"2018","journal-title":"Head 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