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Our study examines the incidence trends of OTC in France from 1990 to 2018, globally and by age; and compares the incidence trends with the evolution of the incidence of other human papilloma virus\u2010unrelated head and neck squamous cell carcinoma, that is, cancers of the remaining subsites of the oral cavity (RSOCC) and laryngeal cancers for the period 1990 to 2018. World age\u2010standardized incidence rates of oral tongue cancers (<jats:italic>C02<\/jats:italic>), cancers of the remaining subsites of the oral cavity (RSOCC, <jats:italic>C03\u201006<\/jats:italic>) and laryngeal cancers (<jats:italic>C32<\/jats:italic>) were estimated using the French National Network of Cancer Registries for the period 1990 to 2018. Trends in national incidence rates were estimated from a mixed\u2010effect Poisson model including age and year effects using penalized splines and a district\u2010random effect. In women aged 30 and 40, a significant increase in OTC incidence was observed, while ROSCC showed a nonsignificant incidence decrease. In young men aged 25, a marginally significant increase of OTC incidence years was observed, while incidence rates of RSOCC significantly declined. The results suggest a tendency towards diverging incidence trends for OTC compared to RSOCC and laryngeal cancer in young adults. The observed trends may reflect changes in underlying exposures or emerging exposures not yet identified, and stress the need to further investigate the etiology of oral tongue cancers.<\/jats:p>","DOI":"10.1002\/ijc.33896","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T09:22:51Z","timestamp":1639128171000},"page":"1301-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Diverging incidence trends of oral tongue cancer compared to other head and neck cancers in young adults in France"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-7869","authenticated-orcid":false,"given":"Sophie","family":"Deneuve","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"INSERM 1296 Unit, Radiations: Defense, Health and Environment Centre L\u00e9on B\u00e9rard  Lyon 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