{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:07:22Z","timestamp":1789013242953,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/1996001\/9454"],"award-info":[{"award-number":["CH\/1996001\/9454"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C16077\/A29186"],"award-info":[{"award-number":["C16077\/A29186"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C500\/A16896"],"award-info":[{"award-number":["C500\/A16896"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017647","name":"Kadoorie Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0900500"],"award-info":[{"award-number":["2016YFC0900500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0900501"],"award-info":[{"award-number":["2016YFC0900501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0900504"],"award-info":[{"award-number":["2016YFC0900504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC1303904"],"award-info":[{"award-number":["2016YFC1303904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91843302"],"award-info":[{"award-number":["91843302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC\u2010PC\u201013049"],"award-info":[{"award-number":["MC\u2010PC\u201013049"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC\u2010PC\u201014135"],"award-info":[{"award-number":["MC\u2010PC\u201014135"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_U137686851"],"award-info":[{"award-number":["MC_U137686851"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00017\/1"],"award-info":[{"award-number":["MC_UU_00017\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_12026\/2"],"award-info":[{"award-number":["MC_UU_12026\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["088158\/Z\/09\/Z"],"award-info":[{"award-number":["088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104085\/Z\/14\/Z"],"award-info":[{"award-number":["104085\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["212946\/Z\/18\/Z"],"award-info":[{"award-number":["212946\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,5,15]]},"abstract":"Abstract<\/jats:title>Two genetic variants that alter alcohol metabolism, ALDH2<\/jats:italic>\u2010rs671 and ADH1B<\/jats:italic>\u2010rs1229984, can modify oesophageal cancer risk associated with alcohol consumption in East Asians, but their associations with other cancers remain uncertain. ALDH2<\/jats:italic>\u2010rs671 G>A and ADH1B<\/jats:italic>\u2010rs1229984 G>A were genotyped in 150\u2009722 adults, enrolled from 10 areas in China during 2004 to 2008. After 11\u2009years' follow\u2010up, 9339 individuals developed cancer. Cox regression was used to estimate hazard ratios (HRs) for site\u2010specific cancers associated with these genotypes, and their potential interactions with alcohol consumption. Overall, the A\u2010allele frequency was 0.21 for ALDH2<\/jats:italic>\u2010rs671 and 0.69 for ADH1B<\/jats:italic>\u2010rs1229984, with A\u2010alleles strongly associated with lower alcohol consumption. Among men, ALDH2<\/jats:italic>\u2010rs671 AA genotype was associated with HR of 0.69 (95% confidence interval: 0.53\u20100.90) for IARC alcohol\u2010related cancers (n\u00a0=\u00a01900), compared to GG genotype. For ADH1B<\/jats:italic>\u2010rs1229984, the HRs of AG and AA vs GG genotype were 0.80 (0.69\u20100.93) and 0.75 (0.64\u20100.87) for IARC alcohol\u2010related cancers, 0.61 (0.39\u20100.96) and 0.61 (0.39\u20100.94) for head and neck cancer (n\u00a0=\u00a0196) and 0.68 (0.53\u20100.88) and 0.60 (0.46\u20100.78) for oesophageal cancer (n\u00a0=\u00a0546). There were no significant associations of these genotypes with risks of liver (n\u00a0=\u00a0651), colorectal (n\u00a0=\u00a0556), stomach (n\u00a0=\u00a0725) or lung (n\u00a0=\u00a01135) cancers. Among male drinkers, the risks associated with higher alcohol consumption were greater among ALDH2<\/jats:italic>\u2010rs671 AG than GG carriers for head and neck, oesophageal and lung cancers (P<\/jats:italic>interaction<\/jats:sub>\u2009<\u2009.02). Among women, only 2% drank alcohol regularly, with no comparable associations observed between genotype and cancer. These findings support the causal effects of alcohol consumption on upper aerodigestive tract cancers, with ALDH2<\/jats:italic>\u2010rs671 AG genotype further exacerbating the risks.<\/jats:p>","DOI":"10.1002\/ijc.33917","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T09:06:30Z","timestamp":1642669590000},"page":"1627-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Alcohol metabolism genes and risks of site\u2010specific cancers in Chinese adults: An 11\u2010year prospective study"],"prefix":"10.1002","volume":"150","author":[{"given":"Pek Kei","family":"Im","sequence":"first","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-6588","authenticated-orcid":false,"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Kartsonaki","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaidong","family":"Du","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Kerosi","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hacker","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Liu","sequence":"additional","affiliation":[{"name":"NCDs Prevention and Control Department Wuzhong CDC Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-0014","authenticated-orcid":false,"given":"Canqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-3870","authenticated-orcid":false,"given":"Jun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin G.","family":"Walters","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-7089","authenticated-orcid":false,"given":"Liming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-0682","authenticated-orcid":false,"given":"Iona Y.","family":"Millwood","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the China Kadoorie Biobank (CKB) Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"FerlayJ ErvikM LamF ColombetM MeryL Pi\u00f1erosM ZnaorA SoerjomataramI&BrayFGlobal Cancer Observatory: Cancer Today. Lyon France: International Agency for Research on Cancer; 2020.https:\/\/gco.iarc.fr\/today\/home. Accessed April 14 2021."},{"key":"e_1_2_11_3_1","first-page":"1","article-title":"Personal habits and indoor combustions. Volume 100 E. A review of human carcinogens","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30231-2"},{"key":"e_1_2_11_5_1","volume-title":"Global Status Report on Alcohol and Health 2018","author":"World Health Organization","year":"2018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33538"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30488-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31772-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2009.00517.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/521201"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0196"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181915"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S76526"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31566"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.6.913"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014855"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.478"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"297","article-title":"Lack of influence of the ADH1B Arg47His genetic polymorphism on risk of colorectal adenoma in middle\u2010aged Japanese men","volume":"12","author":"Yin G","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00519.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0823-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27803"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.205724"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0961"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-2685"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr120"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt078"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-6502-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14873"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30825"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100703"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02079-1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010013"},{"issue":"2","key":"e_1_2_11_33_1","first-page":"99","article-title":"Esophageal cancer and aldehyde dehydrogenase\u20102 genotypes in Japanese males","volume":"5","author":"Yokoyama A","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0462"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-1796-0"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S136898001900452X"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22795"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14508"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14250"},{"issue":"6","key":"e_1_2_11_40_1","first-page":"503","article-title":"Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population","volume":"12","author":"Govind P","year":"2020","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_11_41_1","series-title":"Continuous Update Project Expert Report 2018","volume-title":"Diet, Nutrition, Physical Activity and Cancer: a Global Perspective","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2018"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003178"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00077.x"},{"issue":"1","key":"e_1_2_11_44_1","first-page":"31","article-title":"Alcohol dehydrogenase\u20102 and aldehyde dehydrogenase\u20102 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a Chinese population","volume":"9","author":"Ding J","year":"2008","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21505"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu244"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr067"},{"issue":"4","key":"e_1_2_11_48_1","first-page":"1073","article-title":"Alcohol dehydrogenase\u20102 and aldehyde dehydrogenase\u20102 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males","volume":"11","author":"Cao HX","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq021"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080158"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.173"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08802-4"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10010011"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507234"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28885"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-09614-8_15"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908137116"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.034678"},{"issue":"2","key":"e_1_2_11_59_1","first-page":"163","article-title":"Alcohol and gut\u2010derived inflammation","volume":"38","author":"Bishehsari F","year":"2017","journal-title":"Alcohol Res: Curr Rev"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2013"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32523"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T17:23:02Z","timestamp":1693156982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5,15]]}},"alternative-id":["10.1002\/ijc.33917"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33917","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"assertion":[{"value":"2021-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}