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Their causes are poorly understood, although occupational exposures (especially farming and pesticides) are suspected. The AGRICAN cohort is a prospective study of 181\u2009842 individuals enrolled in 2005 to 2007 who completed an enrolment questionnaire with data on lifelong agricultural exposure. Associations between agricultural exposure and sarcoma overall, gastrointestinal stromal tumors (GIST) and myomatous and fibrous sarcoma together, were analyzed with a Cox model. Until 2015, 188 incident cases of sarcoma were identified. Increased risks were observed (a) among cattle farmers working &lt;10\u2009years (HR<jats:sub>&lt;10years<\/jats:sub>\u00a0=\u00a02.45, 95% CI 1.36\u20104.43) and breeding \u226550 livestock (HR<jats:sub>\u226550animals<\/jats:sub>\u00a0=\u00a03.84, 95% CI 1.60\u20109.22), especially if involved in animal care and building disinfection, (b) in greenhouse production (HR\u00a0=\u00a01.82, 95% CI 1.01\u20103.30) and (c) in field\u2010grown vegetable production (HR\u00a0=\u00a01.49, 95% CI 0.96\u20102.32). Concerning histological subtypes, GIST were positively associated with pesticide use in vineyards (HR\u00a0=\u00a02.24, 95% CI 0.95\u20105.30). For myomatous and fibrous sarcoma, the only increase was seen in field\u2010grown vegetable production (HR\u00a0=\u00a02.37, 95% CI 1.16\u20104.85). In AGRICAN, the risk of sarcomas was increased in several farming activities with differences according to histological subtype.<\/jats:p>","DOI":"10.1002\/ijc.33936","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T05:24:08Z","timestamp":1642656248000},"page":"1792-1803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Agricultural exposure and risk of soft tissue sarcomas and gastrointestinal stromal sarcoma in the <scp>AGRIculture<\/scp> and <scp>CANcer<\/scp> (<scp>AGRICAN<\/scp>) cohort"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-970X","authenticated-orcid":false,"given":"Marine","family":"Renier","sequence":"first","affiliation":[{"name":"INSERM, UMR 1086 ANTICIPE Cancers &amp; Pr\u00e9ventions  Caen France"},{"name":"UFR de Sant\u00e9, Universit\u00e9 de Caen Normandie  Caen 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de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Pons","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1086 ANTICIPE Cancers &amp; Pr\u00e9ventions  Caen France"},{"name":"UFR de Sant\u00e9, Universit\u00e9 de Caen Normandie  Caen France"},{"name":"Cancers &amp; Pr\u00e9ventions, Centre de Lutte Contre le Cancer Fran\u00e7ois Baclesse  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Tual","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1086 ANTICIPE Cancers &amp; Pr\u00e9ventions  Caen France"},{"name":"UFR de Sant\u00e9, Universit\u00e9 de Caen Normandie  Caen France"},{"name":"Cancers &amp; Pr\u00e9ventions, Centre de Lutte Contre le Cancer Fran\u00e7ois Baclesse  Caen 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