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A total of 83\u2009000 new cases of HL and 23\u2009000 deaths from HL were estimated in 2020. In general, incidence and mortality rates were consistently higher in males (50% more cases and deaths than females) across world regions and countries. Incidence rates varied markedly by world region, at least 10\u2010fold in both sexes, with the highest incidence rates observed in Southern Europe. Mortality exhibited an inverse pattern compared to incidence, with rates elevated in Western Asia and Northern Africa. The number of HL incident cases is predicted to rise to around 107\u2009000 cases (a 30% increase) by 2040 due to demographic changes, assuming global rates in 2020 remains unchanged. The findings provide a baseline and impetus for developing strategies that aim to reduce the burden of HL in future decades.<\/jats:p>","DOI":"10.1002\/ijc.33948","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T11:39:18Z","timestamp":1643197158000},"page":"1941-1947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Global patterns of Hodgkin lymphoma incidence and mortality in 2020 and a prediction of the future burden in 2040"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-9183","authenticated-orcid":false,"given":"Deependra","family":"Singh","sequence":"first","affiliation":[{"name":"Cancer Surveillance Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Vaccarella","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gini","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neimar","family":"De Paula Silva","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Steliarova\u2010Foucher","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-7787","authenticated-orcid":false,"given":"Freddie","family":"Bray","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"SwerdlowSH CampoE HarrisNL et al. 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