{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:12:28Z","timestamp":1747149148998,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with the most extensive breast density, have a 4\u2010 to 6\u2010fold higher cancer risk than women with the lowest density. This cross\u2010sectional study evaluated associations of cumulative mammographic density in two distinct ethnic groups with the respective age\u2010specific breast cancer incidences in the population. The study compared four cohorts of 200 women each aged 35 to 49 and 50 to 74, representing Jewish and Arab ethnicity. Breast density measures were calculated from screening mammograms, using a thresholding software (Cumulus). Breast cancer specific incidence values were obtained from the National Cancer Registry. The percent mammographic density was lower for women aged 50 to 74 than 35 to 49\u2009years, both for Jews: 11.7 vs 23.1 and for Arabs: 11.6 vs 18.3. In contrast, the cumulative density increased with age, from 37.30 to 181.24 in Jews, compared to 21.26 to 108.03 in Arabs. Similar trends in breast cancer incidence rates per 100\u2009000 in the Israeli population were apparent, with an increase from 92.95 to 381.91 in Jews, compared to 48.6 to 244.44 in Arabs. Comparing cumulative density of the cohort with respective age\u2010specific breast cancer incidence in the population yielded a highly significant correlation: Jews; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.97, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001 and Arabs: <jats:italic>r<\/jats:italic>\u00a0=\u00a0.86, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007. A strong association was found between the log of cumulative density and the log of cancer incidence, as well. Our study identified correlations between cumulative mammographic density and breast cancer incidence in two distinct populations. The findings should prompt research to enhance our understanding of the pathogenesis of breast cancer, and lead to novel insights into measures of prevention.<\/jats:p>","DOI":"10.1002\/ijc.33957","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T06:01:14Z","timestamp":1644213674000},"page":"1968-1977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between cumulative mammographic density and age\u2010specific incidence of breast cancer: A biethnic study in Israel"],"prefix":"10.1002","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-7181","authenticated-orcid":false,"given":"Anath A.","family":"Flugelman","sequence":"first","affiliation":[{"name":"Rambam Health Care Campus Technion\u2010Israel Institute of Technology  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anya","family":"Burton","sequence":"additional","affiliation":[{"name":"National Cancer Registration and Analysis Service  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lital","family":"Keinan\u2010Boker","sequence":"additional","affiliation":[{"name":"National Cancer Registry Center for Disease Control, Ministry of Health  Ramat Gan"},{"name":"School of Public Health University of Haifa  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nili","family":"Stein","sequence":"additional","affiliation":[{"name":"The Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Clalit National Cancer Control Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafna","family":"Kutner","sequence":"additional","affiliation":[{"name":"The Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Clalit National Cancer Control Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Shemesh","sequence":"additional","affiliation":[{"name":"The Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Clalit National Cancer Control Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Boyd","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"volume-title":"Breast Cancer","author":"World Health Organization","key":"e_1_2_10_2_1"},{"key":"e_1_2_10_3_1","first-page":"14","volume-title":"WHO Classification of Tumours of the Breast","author":"Lakhani 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