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We prospectively examined the relationship between CRP trajectory patterns and new\u2010onset cancers among 52\u2009276 participants. Latent mixture modeling was used to identify CRP trajectories. Cox proportional hazards regression models were used to evaluate the association between CRP trajectory patterns and the risk of overall and specific\u2010site cancer. Four CRP trajectories patterns were identified: low\u2010stable pattern (n\u00a0=\u00a043\u2009258), moderate\u2010increasing pattern (n\u00a0=\u00a02591), increasing\u2010decreasing pattern (n\u00a0=\u00a02068) and elevated\u2010decreasing pattern (n\u00a0=\u00a04359). Relative to the low\u2010stable pattern, the moderate\u2010increasing trajectory pattern was associated with an elevated risk of overall, lung, breast, leukemia, bladder, stomach, colorectal, liver, gallbladder or extrahepatic bile duct cancer and leukemia. Participants in the increasing\u2010decreasing trajectory pattern were associated with an elevated risk of overall, lung, breast, bladder, pancreatic and liver cancer. The increasing\u2010decreasing trajectory pattern was also associated with decreased risk of colorectal cancer in the multivariate analyses. Elevated\u2010decreasing trajectory pattern was associated with increased risk of leukemia and decreased risk of esophageal and colorectal cancer. CRP trajectories play an important role in the occurrence of cancers, especially in the lung, breast, bladder, stomach, colorectal, liver, gallbladder and extrahepatic bile duct cancer and leukemia.<\/jats:p>","DOI":"10.1002\/ijc.34012","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T09:34:48Z","timestamp":1648978488000},"page":"297-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["C\u2010reactive protein trajectories and the risk of all cancer types: A prospective cohort study"],"prefix":"10.1002","volume":"151","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"},{"name":"Key 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