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A multicenter database of patients with adrenal metastases of any histology treated with SBRT (biologically effective dose, BED10\u2009\u226550\u2009Gy, \u226412 fractions) was analyzed. Details on dose\u2010volume parameters were required (planning target volume: PTV\u2010D98%, PTV\u2010D50%, PTV\u2010D2%; gross tumor volume: GTV\u2010D50%, GTV\u2010mean). Cut\u2010points for LRR were optimized using the R maxstat package. One hundred and ninety\u2010six patients with 218 lesions were included, the largest histopathological subgroup was adenocarcinoma (n\u00a0=\u00a0101). Cut\u2010point optimization resulted in significant cut\u2010points for PTV\u2010D50% (BED10: 73.2\u2009Gy; <jats:italic>P<\/jats:italic>\u00a0=\u2009.003), GTV\u2010D50% (BED10: 74.2\u2009Gy; <jats:italic>P<\/jats:italic>\u00a0=\u2009.006), GTV\u2010mean (BED10: 73.0\u2009Gy; <jats:italic>P<\/jats:italic>\u00a0=\u2009.007), and PTV\u2010D2% (BED10: 78.0\u2009Gy; <jats:italic>P<\/jats:italic>\u00a0=\u2009.02) but not for the PTV\u2010D98% (<jats:italic>P<\/jats:italic>\u00a0=\u2009.06). Differences in LRR were clinically relevant (LRR \u2265 doubled for cut\u2010points that were not achieved). Further dose\u2010escalation was not associated with further improved LRR. PTV\u2010D50%, GTV\u2010D50%, and GTV\u2010mean cut\u2010points were also associated with significantly improved LRR in the adenocarcinoma subgroup. Separate dose optimizations indicated a lower cut\u2010point for the PTV\u2010D50% (BED10: 69.1\u2009Gy) in adenocarcinoma lesions, other values were similar (&lt;2% difference). Associations of cut\u2010points with overall survival (OS) and progression\u2010free survival were not significant but durable freedom from local recurrence was associated with OS in a landmark model (<jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). To achieve a significant improvement of LRR for adrenal SBRT, a moderate escalation of PTV\u2010D50% BED10\u2009&gt;73.2\u2009Gy (adenocarcinoma: 69.1\u2009Gy) should be considered.<\/jats:p>","DOI":"10.1002\/ijc.34017","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T04:53:55Z","timestamp":1649220835000},"page":"412-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Stereotactic body radiotherapy of adrenal metastases\u2014A dose\u2010finding study"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-3332","authenticated-orcid":false,"given":"Daniel","family":"Buergy","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie und Radioonkologie Universit\u00e4tsmedizin Mannheim, Medizinische Fakult\u00e4t Mannheim, Universit\u00e4t Heidelberg  Mannheim 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